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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Evaluation of Injectable Naloxone-Releasing Hydrogels
ACS applied bio materials, v 3(11), pp 7858-7864
16 Nov 2020
PMID: 35019526
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The opioid epidemic in the United States is a serious public health crisis affecting over 1.7 million Americans. In the last two decades, almost 450 000 people have died from an opioid overdose, with nearly 20% of these deaths occurring in 2017 and 2018 alone. During an overdose, overstimulation of the μ-opioid receptor leads to severe and potentially fatal respiratory depression. Naloxone is a competitive μ-opioid-receptor antagonist that is widely used to displace opioids and rescue from an overdose. Here, we describe the development of a slow-release, subcutaneous naloxone formulation for potential management of opioid overdose, chronic pain, and opioid-induced constipation. Naloxone is loaded into self-assembling peptide hydrogels for controlled drug release. The mechanical, chemical, and structural properties of the nanofibrous hydrogel enable subcutaneous administration and slow, diffusion-based release kinetics of naloxone over 30 days in vitro. The naloxone hydrogel scaffold showed cytocompatibility and did not alter the β-sheet secondary structure or thixotropic properties characteristic of self-assembling peptide hydrogels. Our results show that this biocompatible and injectable self-assembling peptide hydrogel may be useful as a vehicle for tunable, sustained release of therapeutic naloxone. This therapy may be particularly suited for preventing renarcotization in patients who refuse additional medical assistance following an overdose.
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Details
- Title
- Evaluation of Injectable Naloxone-Releasing Hydrogels
- Creators
- Kaytlyn M. Crowe - New Jersey Institute of TechnologyZain Siddiqui - New Jersey Institute of TechnologyVictoria Harbour - New Jersey Institute of TechnologyKaKyung Kim - New Jersey Institute of TechnologyShareef Syed - New Jersey Institute of TechnologyReshma Paul - New Jersey Institute of TechnologyAbhishek Roy - New Jersey Institute of TechnologyRuhi Naik - New Jersey Institute of TechnologyKayla Mitchell - New Jersey Institute of TechnologyAryan Mahajan - New Jersey Institute of TechnologyBiplab Sarkar - New Jersey Institute of TechnologyVivek A. Kumar - New Jersey Institute of Technology
- Publication Details
- ACS applied bio materials, v 3(11), pp 7858-7864
- Publisher
- American Chemical Society (ACS)
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000604607600060
- Scopus ID
- 2-s2.0-85097061327
- Other Identifier
- 991021956615204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology