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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Evaluation of change in CD4+ cell counts in AIDS clinical trials
Statistical methods in medical research, v 17(2), pp 141-150
Apr 2008
PMID: 17698930
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate the antiretroviral activity of antiretroviral agents and to compare the effects of two different antiretroviral agents, we propose a non-parametric mixed-effects model to investigate change of CD4+ counts. The proposed model and methods are applied to analyse the data from PACTG345 study. Population and individual patterns of change of CD4+ counts and a reference band are obtained. Our results indicate that treatment with high-dose ritonavir is significantly superior compared with low-dose ritonavir.
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Details
- Title
- Evaluation of change in CD4+ cell counts in AIDS clinical trials
- Creators
- H Liang - University of Rochester Medical Center
- Publication Details
- Statistical methods in medical research, v 17(2), pp 141-150
- Publisher
- Sage
- Grant note
- R01 AI062247 / NIAID NIH HHS R01 AI062247-02 / NIAID NIH HHS R01 AI059773 / NIAID NIH HHS R01 AI062247-03 / NIAID NIH HHS R01 AI059773-02 / NIAID NIH HHS AI59773 / NIAID NIH HHS AI62247 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000255833400002
- Scopus ID
- 2-s2.0-43949143825
- Other Identifier
- 991019320404104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Health Care Sciences & Services
- Mathematical & Computational Biology
- Medical Informatics
- Statistics & Probability