Journal article
Evaluation of evoked responses to pulse-matched high frequency and intermittent theta burst transcranial magnetic stimulation using simultaneous functional near-infrared spectroscopy
Neurophotonics (Print), v 4(4), pp 041405-041405
01 Oct 2017
PMID: 28840157
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transcranial magnetic stimulation (TMS) is a noninvasive method used to excite or inhibit cortical activity for experimental, diagnostic, and therapeutic interventions. However, nonmotor regions of the brain targeted in TMS therapies, such as the dorsolateral prefrontal cortex (DLPFC), offer no extrinsic response to stimulation, resulting in a need for a practical method for the evaluation of treatment. We sought to determine the capability of a continuous-wave light emitting diodes (LED)-based functional near-infrared spectroscopy (fNIRS) system to measure evoked cortical hemoglobin changes in the DLPFC during the simultaneous application of TMS to the left-DLPFC under brief stimulation paradigms used in the clinic. Seventeen healthy participants received short TMS trains at F3 in four different stimulation conditions (single pulse, high frequency, intermittent theta burst, and sham) while adjacent fNIRS measurements were recorded. Ten 2-s trains of each stimulation type were delivered with an intertrial interval of 40 s. Results indicated that high-frequency stimulation produces a larger and more evident response than other measured conditions. These findings show that a continuous-wave LED-based fNIRS system can be used to measure TMS-evoked responses and that future TMS applications can benefit from concurrent assessment of localized cortical activation changes.
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Details
- Title
- Evaluation of evoked responses to pulse-matched high frequency and intermittent theta burst transcranial magnetic stimulation using simultaneous functional near-infrared spectroscopy
- Creators
- Adrian Curtin - bDrexel University, School of Biomedical Engineering, Science, and Health Systems, Philadelphia, Pennsylvania, United StatesJunfeng Sun - aShanghai Jiao Tong University, School of Biomedical Engineering, Shanghai, ChinaHasan Ayaz - dChildren's Hospital of Philadelphia, The Division of General Pediatrics, Philadelphia, Pennsylvania, United StatesZhenying Qian - eShanghai Jiao Tong University, School of Medicine, Shanghai Mental Health Center, Shanghai, ChinaBanu Onaral - bDrexel University, School of Biomedical Engineering, Science, and Health Systems, Philadelphia, Pennsylvania, United StatesJijun Wang - eShanghai Jiao Tong University, School of Medicine, Shanghai Mental Health Center, Shanghai, ChinaShanbao Tong - aShanghai Jiao Tong University, School of Biomedical Engineering, Shanghai, China
- Publication Details
- Neurophotonics (Print), v 4(4), pp 041405-041405
- Publisher
- Society of Photo-Optical Instrumentation Engineers
- Grant note
- YG2015ZD12 / Med-X Research Fund of Shanghai Jiao Tong Unviversity 61673267 / National Natural Science Foundation of China (NSFC) (http://dx.doi.org/10.13039/501100001809) 16ZR1446600 / Natural Science Foundation of Shanghai (http://dx.doi.org/10.13039/100007219)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000417979700004
- Scopus ID
- 2-s2.0-85028522110
- Other Identifier
- 991014878094804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Optics