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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Evaluation of intervention components to maximize outcomes of behavioral obesity treatment delivered online: A factorial experiment following the multiphase optimization strategy framework
Contemporary clinical trials, v 100, 106217
Jan 2021
PMID: 33197609
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Behavioral lifestyle intervention (BLI) is recommended as a first-line treatment for obesity. While BLI has been adapted for online delivery to improve potential for dissemination while reducing costs and barriers to access, weight losses are typically inferior to gold standard treatment delivered in-person. It is therefore important to refine and optimize online BLI in order to improve the proportion of individuals who achieve a minimum clinically significant weight loss and mean weight loss.
Five experimental intervention components will be tested as adjuncts to an established 12-month online BLI: virtual reality for BLI skills training, interactive video feedback, tailored intervention to promote physical activity, skills for dysregulated eating, and social support combined with friendly competition. Following the Multiphase Optimization Strategy (MOST) framework, the components will first be refined and finalized during Preparation Phase pilot testing and then evaluated in a factorial experiment with 384 adults with overweight or obesity. A priori optimization criteria that balance efficacy and efficiency will be used to create a finalized treatment package that produces the best weight loss outcomes with the fewest intervention components. Mediation analysis will be conducted to test hypothesized mechanisms of action and a moderator analysis will be conducted to understand for whom and under what circumstances the interventions are effective.
This study will provide important information about intervention strategies that are useful for improving outcomes of online BLI. The finalized treatment package will be suitable for testing in a future randomized trial in the MOST Evaluation Phase.
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Details
- Title
- Evaluation of intervention components to maximize outcomes of behavioral obesity treatment delivered online: A factorial experiment following the multiphase optimization strategy framework
- Creators
- J. Graham Thomas - Brown UniversityCarly M. Goldstein - Miriam HospitalDale S. Bond - Miriam HospitalJason Lillis - Miriam HospitalEric B. Hekler - Department of Family Medicine and Public Health, University of California, San Diego (UCSD), Center for Wireless and Population Health Systems, Qualcomm Institute at UCSD, 9500 Gilman Ave., San Diego, CA 92093, USA.Jessica A. Emerson - Miriam HospitalHallie M. Espel-Huynh - Miriam HospitalStephanie P. Goldstein - Miriam HospitalShira I. Dunsiger - Brown UniversityE. Whitney Evans - Miriam HospitalMeghan L. Butryn - Drexel UniversityJeff Huang - Brown UniversityRena R. Wing - Miriam Hospital
- Publication Details
- Contemporary clinical trials, v 100, 106217
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Center for Weight, Eating and Lifestyle Science (WELL) [Historical]
- Web of Science ID
- WOS:000756199400006
- Scopus ID
- 2-s2.0-85096719953
- Other Identifier
- 991019168755404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy