Journal article
Evaluation of light detector surface area for functional Near Infrared Spectroscopy
Computers in biology and medicine, v 89
01 Oct 2017
PMID: 28787647
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Functional Near Infrared Spectroscopy (fNIRS) is an emerging neuroimaging technique that utilizes near infrared light to detect cortical concentration changes of oxy-hemoglobin and deoxy-hemoglobin non-invasively. Using light sources and detectors over the scalp, multi-wavelength light intensities are recorded as time series and converted to concentration changes of hemoglobin via modified Beer-Lambert law. Here, we describe a potential source for systematic error in the calculation of hemoglobin changes and light intensity measurements. Previous system characterization and analysis studies looked into various fNIRS parameters such as type of light source, number and selection of wavelengths, distance between light source and detector. In this study, we have analyzed the contribution of light detector surface area to the overall outcome. Results from Monte Carlo based digital phantoms indicated that selection of detector area is a critical system parameter in minimizing the error in concentration calculations. The findings here can guide the design of future fNIRS sensors.
•Detector area as a potential source of error in fNIRS data processing is proposed.•Detector area size affects DPF stability.•Unstable DPF causes relative larger error in hemoglobin concentration calculation.•Different source detector separation also affects DPF stability.
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Details
- Title
- Evaluation of light detector surface area for functional Near Infrared Spectroscopy
- Creators
- Lei Wang - School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA, USAHasan Ayaz - School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA, USAMeltem Izzetoglu - School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA, USABanu Onaral - School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA, USA
- Publication Details
- Computers in biology and medicine, v 89
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Information Science; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000413376600007
- Scopus ID
- 2-s2.0-85026767487
- Other Identifier
- 991014877804204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology
- Computer Science, Interdisciplinary Applications
- Engineering, Biomedical
- Mathematical & Computational Biology