Journal article
Evaluation of the Pediatric Research Participation Questionnaire for Measuring Attitudes Toward Cancer Clinical Trials Among Adolescents and Young Adults
Journal of adolescent and young adult oncology, v 8(4), pp 423-433
01 Aug 2019
PMID: 31025898
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose:
Reasons for the relatively low rates of adolescent and young adults (AYA) enrollment in cancer clinical trials in the United States require further empirical examination. In addition to structural factors such as lack of access and insurance barriers, attitudes toward clinical trials may be important to consider. This study aimed to evaluate and validate the Pediatric Research Participation Questionnaire (PRPQ)—a measure of attitudes to clinical trials adapted for AYA (15–29) with cancer and their caregivers.
Methods:
One hundred twenty-four AYA and 94 caregivers completed the PRPQ-AYA and measures of clinical trial knowledge and developmental/emotional maturity. Factor analysis evaluated the PRPQ-AYA structure, interitem reliability was computed, and Pearson correlations examined associations of validation measures with factor scores and computed scores reflecting perceived barriers, perceived benefits, and decision balance.
Results:
Confirmatory factor analysis did not confirm the prior PRPQ factor structure. Exploratory factor analysis suggested a new four-factor structure for: AYA (1) trust/mistrust, (2) barriers/costs, (3) support for participation, and (4) incentives; and caregivers (1) trust/access, (2) mistrust/costs, (3) support for participation, and (4) risks to AYA. Factor scores and barriers, benefits, and decision balance scores demonstrated acceptable interitem reliability and were significantly correlated with clinical trial knowledge and emotional maturity in the expected direction.
Conclusion:
PRPQ-AYA factor structure for AYA and caregivers varied and should be interpreted cautiously due to limited power. Simple solutions of perceived benefits, perceived barriers, and decision balance were reliable and valid and provide important information to address and engage AYA through the clinical trial informed consent process.
Metrics
Details
- Title
- Evaluation of the Pediatric Research Participation Questionnaire for Measuring Attitudes Toward Cancer Clinical Trials Among Adolescents and Young Adults
- Creators
- Lamia P. Barakat - Children's Hospital of PhiladelphiaEvelyn Stevens - Children's Hospital of PhiladelphiaYimei Li - Children's Hospital of PhiladelphiaAnne Reilly - Children's Hospital of PhiladelphiaJanet A. Deatrick - University of PennsylvaniaNaomi E. Goldstein - Drexel UniversityLisa A. Schwartz - Children's Hospital of Philadelphia
- Publication Details
- Journal of adolescent and young adult oncology, v 8(4), pp 423-433
- Publisher
- Mary Ann Liebert, Inc., publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000465856100001
- Scopus ID
- 2-s2.0-85070560812
- Other Identifier
- 991019167985104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology