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Journal article
Evaluation of the interfractional biological effective dose (BED) variation in MammoSite high dose rate brachytherapy
Journal of applied clinical medical physics, v 11(3)
10 Jun 2010
PMID: 20717092
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Abstract
The objective of this work is to evaluate the interfractional biological effective dose (BED) variation in MammoSite high dose rate (HDR) brachytherapy. Dose distributions of 19 patients who received 34 Gy in 10 fractions were evaluated. A method was employed to account for nonuniform dose distribution in the BED calculation. Furthermore, a range of α/β values was utilized for specific clinical end points: fibrosis, telangiectasia, erythema, desquamation and breast carcinoma. Two scenarios were simulated to calculate the BED value using: i) the same dose distribution of fraction 1 over fractions 2–10 (constant case, CC), and ii) the actual delivered dose distribution for each fraction 1–10 (interfraction dose variation case, IVC). Although the average BED difference (IVC – CC) was
<
0.7
Gy for all clinical endpoints, the range of difference for fibrosis and telangiectasia reached
−
11
%
to
+
3
%
and
−
9
%
to
+
9
%
for one of the patients, respectively. By disregarding high inhomogeneity in HDR brachytherapy, the conventional BED calculation tends to overestimate the BED for fibrosis by 16% on average, while it underestimates the BED for erythema (7.6%) and desquamation (10.2%). In conclusion, the BED calculation accounting for the nonuniform dose distribution provides a more clinically relevant description of the clinical delivered dose. Though the average BED difference was clinically insignificant, the maximum difference of BED for late effects can differ by a single fractional dose (10%) for a specific patient due to the interfraction dose variation in MammoSite treatment.
PACS number: 87.53.Jw
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Details
- Title
- Evaluation of the interfractional biological effective dose (BED) variation in MammoSite high dose rate brachytherapy
- Creators
- Yongbok Kim - Allegheny General HospitalE. Day Werts - Allegheny General HospitalMark G. Trombetta - Allegheny General HospitalMoyed Miften - University of Denver
- Publication Details
- Journal of applied clinical medical physics, v 11(3)
- Publisher
- John Wiley and Sons Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000281806200010
- Scopus ID
- 2-s2.0-77956988619
- Other Identifier
- 991019167339304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging