Journal article
Everyday executive functions in Down syndrome from early childhood to young adulthood: evidence for both unique and shared characteristics compared to youth with sex chromosome trisomy (XXX and XXY)
Frontiers in behavioral neuroscience, Vol.9
20 Oct 2015
PMID: 26539087
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Executive functions (EF) are thought to be impaired in Down syndrome (DS) and sex chromosome trisomy (Klinefelter and Trisomy X syndromes; +1X). However, the syndromic specificity and developmental trajectories associated with EF difficulties in these groups are poorly understood. The current investigation (a) compared everyday EF difficulties in youth with DS, +1X, and typical development (TD); and (b) examined relations between age and EF difficulties in these two groups and a TD control group cross-sectionally. Study 1 investigated the syndromic specificity of EF profiles on the Behavior Rating Inventory of Executive Function (BRIEF) in DS (n = 30), +1X = 30), and a TD group (n = 30), ages 5-18 years. Study 2 examined age effects on EF in the same cross-sectional sample of participants included in Study 1. Study 3 sought to replicate Study 2's findings for DS by examining age-EF relations in a large independent sample of youth with DS (n = 85) and TD = 43), ages 4-24 years. Study 1 found evidence for both unique and shared EF impairments for the DS and +1X groups. Most notably, youth with +1X had relatively uniform EF impairments on the BRIEF scales, while the DS group showed an uneven BRIEF profile with relative strengths and weaknesses. Studies 2 and 3 provided support for fairly similar age-EF relations in the DS and TD groups. In contrast, for the +1X group, findings were mixed; 6 BRIEF scales showed similar age-EF relations to the TD group and 2 showed greater EF difficulties at older ages for +1X. These findings will be discussed within the context of efforts to identify syndrome specific cognitive-behavioral profiles for youth with different genetic syndromes in order to inform basic science investigations into the etiology of EF difficulties in these groups and to develop treatment approaches that are tailored to the needs of these groups.
Metrics
6 Record Views
Details
- Title
- Everyday executive functions in Down syndrome from early childhood to young adulthood: evidence for both unique and shared characteristics compared to youth with sex chromosome trisomy (XXX and XXY)
- Creators
- Nancy Raitano Lee - NIMH, Child Psychiat Branch, Bethesda, MD 20892 USAPayal Anand - Univ Arizona, Dept Psychol, Tucson, AZ 85721 USAElizabeth Will - Colorado State Univ, Human Dev & Family Studies, Ft Collins, CO 80523 USAElizabeth I. Adeyemi - NIMH, Child Psychiat Branch, Bethesda, MD 20892 USALiv S. Clasen - NIMH, Child Psychiat Branch, Bethesda, MD 20892 USAJonathan D. Blumenthal - NIMH, Child Psychiat Branch, Bethesda, MD 20892 USAJay N. Giedd - NIMH, Child Psychiat Branch, Bethesda, MD 20892 USALisa A. Daunhauer - Colorado State Univ, Human Dev & Family Studies, Ft Collins, CO 80523 USADeborah J. Fidler - Colorado State Univ, Human Dev & Family Studies, Ft Collins, CO 80523 USAJamie O. Edgin - Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA
- Publication Details
- Frontiers in behavioral neuroscience, Vol.9
- Publisher
- Frontiers Media Sa
- Number of pages
- 15
- Grant note
- LuMind Research Down Syndrome Foundation ZIA MH00279413 / Intramural Research Program of National Institutes of Health, National Institute of Mental Health R01HD07434601A1 / extramural research program of the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development Research Down Syndrome H133G100197 / US Department of Education/National Institute of Disability and Rehabilitation Research; US Department of Education R324A110136 / US Department of Education/Institute for Education Sciences; US Department of Education
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychology
- Identifiers
- 991019167786104721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences