Journal article
Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
Science (American Association for the Advancement of Science), v 290(5500), pp 2302-2303
22 Dec 2000
PMID: 11125142
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the
IDE
gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the
IDE
gene.
Metrics
Details
- Title
- Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
- Creators
- Lars Bertram - Pediatrics and GeneticsDeborah Blacker - Massachusetts General HospitalKristina Mullin - Pediatrics and GeneticsDevon Keeney - Pediatrics and GeneticsJennifer Jones - Pediatrics and GeneticsSanjay Basu - Genetics and Aging Unit, Department of NeurologyStephen Yhu - Pediatrics and GeneticsMelvin G. McInnis - Johns Hopkins UniversityRodney C. P. Go - University of AlabamaKonstantinos Vekrellis - Brigham and Women's HospitalDennis J. Selkoe - Brigham and Women's HospitalAleister J. Saunders - Pediatrics and GeneticsRudolph E. Tanzi - Pediatrics and Genetics
- Publication Details
- Science (American Association for the Advancement of Science), v 290(5500), pp 2302-2303
- Publisher
- American Association for the Advancement of Science (AAAS)
- Number of pages
- 2
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000165995800042
- Scopus ID
- 2-s2.0-0034704198
- Other Identifier
- 991021448059004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity