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Journal article
Evidence for a regional specificity in the density and distribution of noradrenergic varicosities in rat cortex
Journal of comparative neurology (1911), v 521(10), pp 2195-2207
01 Jul 2013
PMID: 23184811
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The brainstem nucleus locus coeruleus (LC) is the sole source of norepinephrine (NE)-containing fibers in the mammalian cortex. Previous studies suggest that the density of noradrenergic fibers in rat is relatively uniform across cortical regions and that cells in the nucleus discharge en masse. This implies that activation of the LC results in equivalent release of NE throughout the cortex. However, it is possible that there could be differences in the density of axonal varicosities across regions, and that these differences, rather than a difference in fiber density, may contribute to the regulation of NE efflux. Quantification of dopamine -hydroxylase (DH)-immunostained varicosities was performed on several cortical regions and in the ventral posterior medial (VPM) thalamus by using unbiased sampling methods. The density of DH varicosities is greater in the prefrontal cortex than in motor, somatosensory, or piriform cortices, greater in superficial than in deep layers of cortex, and greater in the VPM than in the somatosensory cortex. Our results provide anatomical evidence for non-uniform release of NE across functionally discrete cortical regions. This morphology may account for a differential, region-specific, impact of LC output on different cortical areas. J. Comp. Neurol. 521:21952207, 2013. (c) 2012 Wiley Periodicals, Inc.
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Details
- Title
- Evidence for a regional specificity in the density and distribution of noradrenergic varicosities in rat cortex
- Creators
- Kara L. Agster - Drexel UniversityCarlos A. Mejias-Aponte - National Institute on Drug AbuseBrian D. Clark - Drexel UniversityBarry D. Waterhouse - Drexel University
- Publication Details
- Journal of comparative neurology (1911), v 521(10), pp 2195-2207
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- Pennsylvania Department of Health DA017960 / National Institute of Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) T32 NINDS NS 007440 / National Institute of Neurological Disorders and Stroke fellowship R21MH087921 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01DA017960 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission T32NS007440 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; [Retired Faculty]
- Web of Science ID
- WOS:000318160400002
- Scopus ID
- 2-s2.0-84876740290
- Other Identifier
- 991019168721804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Zoology