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Evidence of mnt-myc antagonism revealed by mnt gene deletion
Journal article   Peer reviewed

Evidence of mnt-myc antagonism revealed by mnt gene deletion

Peter J Hurlin, Zi-Qiang Zhou, Kazuhito Toyo-Oka, Sara Ota, William L Walker, Shinji Hirotsune and Anthony Wynshaw-Boris
Cell cycle (Georgetown, Tex.), v 3(2), pp 97-99
Feb 2004
PMID: 14712062
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors Cell Division - physiology Cell Transformation, Neoplastic - metabolism DNA-Binding Proteins - metabolism Gene Deletion Gene Expression Regulation, Neoplastic - physiology Genes, Suppressor Mammary Neoplasms, Experimental - metabolism Mice Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - genetics Repressor Proteins Transcription Factors Transcription, Genetic - genetics
Myc proteins play a central role in promoting cell proliferation and contribute to a diverse array of cancers. My function appears completely dependent on heterodimerization with Max through related bHLHZip regions. Max interaction with Myc is required for DNA binding at so-called E-box sequences and Myc-dependent transcriptional activation. The repressor with similar DNA binding specificity raised the possibility that Mnt may serve a general role as a Myc antagonist.

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14 citations in Web of Science

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Cell Biology
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