Journal article
Evidence that reciprocal hindlimb scratching elicited in mice by intrathecal administration of muscarinic agonists is mediated through M 1 type receptors
Life sciences (1973), v 41(15), pp 1831-1836
1987
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Abstract
Intrathecal (IT) administration of pilocarpine to mice produces a vigorous and dose-related reciprocal hindlimb scratching (RHS) response (ED
50 = 0.6
μg) that is potently blocked by simultaneous IT administration of atropine (ID
50 = 0.002
μg). We now report that RHS is (1) also elicited by the more selective M
1 agonist McN-A-343-11 (ED
50 = 11.6
μg), (2) blocked by the selective M
1 antagonist pirenzepine (ID
50 = 0.001
μg), and (3) is not blocked by the selective M
2 antagonist AF-DX 116 BS at a dose up to 100 times the ID
50 dose of pirenzepine. These results extend our earlier findings and suggest that the RHS elicited in mice by IT injection of muscarinic agonists is mediated through pirenzepine-sensitive (presumably M
1) receptors and that RHS may be a convenient
in vivo centrally mediated M
1 endpoint.
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Details
- Title
- Evidence that reciprocal hindlimb scratching elicited in mice by intrathecal administration of muscarinic agonists is mediated through M 1 type receptors
- Creators
- Robert B. Raffa - JanssenJoanne R. Mathiasen - JanssenTamara L. Goode - JanssenJeffry L. Vaught - Janssen
- Publication Details
- Life sciences (1973), v 41(15), pp 1831-1836
- Publisher
- Elsevier; OXFORD
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1987J992400008
- Scopus ID
- 2-s2.0-0023513560
- Other Identifier
- 991021900192704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy