Journal article
Evidence that the Y chromosome influences autoimmune disease in male and female mice
Proceedings of the National Academy of Sciences - PNAS, v 103(21), pp 8024-8029
23 May 2006
PMID: 16702550
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Experimental allergic encephalomyelitis (EAE), an autoimmune model of multiple sclerosis, is a complex disease influenced by genetic, intrinsic, and environmental factors. In this study, we questioned whether parent-of-origin effects influence EAE, using reciprocal F2 intercross progeny generated between EAE-susceptible SJL/J (S) and EAE-resistant B10.S/SgMcdJ (B) mice. EAE susceptibility and severity were found to be different in female BS x BS intercross mice as compared with females from the three other birth crosses (BS x SB, SB x SB, and SB x BS), and in fact, both traits in female mice resembled those of their male siblings. This masculinization is associated with transmission of the SJL/J Y chromosome and an increased male-to-female sex ratio. Related studies using progeny of C57BL/6J Y-chromosome substitution strains demonstrate that the Y chromosome again influences EAE in both male and female mice, and that the disease course in females resembles that of their male littermates. Importantly, these data provide experimental evidence supporting the existence of a Y-chromosome polymorphism capable of modifying autoimmune disease susceptibility in both males and females.
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Details
- Title
- Evidence that the Y chromosome influences autoimmune disease in male and female mice
- Creators
- Cory Teuscher - Department of Medicine and Pathology and Medical Biostatistics, University of Vermont, Burlington, VT 05405, USA. c.teuscher@uvm.eduRajkumar NoubadeKaren SpachBenjamin McElvanyJanice Y BunnParley D FillmoreJames F ZacharyElizabeth P Blankenhorn
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 103(21), pp 8024-8029
- Publisher
- PNAS; United States
- Grant note
- RG-3129 / CSR NIH HHS NS36526 / NINDS NIH HHS R01 AI041747 / NIAID NIH HHS P01 AI045666 / NIAID NIH HHS AI41747 / NIAID NIH HHS AI4515 / NIAID NIH HHS R01 NS036526 / NINDS NIH HHS AI45666 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000237853900018
- Scopus ID
- 2-s2.0-33744504438
- Other Identifier
- 991014878580504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology