Journal article
Evolution and functional divergence of the Fidgetin family
Biochimica et biophysica acta. Molecular cell research, v 1872(1), 119870
29 Oct 2024
PMID: 39481482
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Fidgetin (FIGN) family, which comprises FIGN, Fidgetin-like 1 (FIGNL1), and Fidgetin-like 2 (FIGNL2), is a vital group of microtubule-severing proteins. These proteins feature a conserved AAA+ domain essential for ATPase activity and a hexameric assembly. This review provides an in-depth analysis of the evolution and functional divergence of the FIGN family members, highlighting their role in the dynamic organization of the cytoskeleton. We further explore their broader biological functions across various species, systems, and subcellular localization. Although the FIGN family is conserved, each member exhibits unique structural characteristics and functions that reflect their evolutionary adaptations. FIGNL1 is found across animal species, while FIGNL2 is specific to vertebrates, thereby indicating its more recent evolutionary origin. Moreover, synteny analysis has revealed that FIGN is located in a more conserved genomic region compared to FIGNL2, which has undergone substantial evolutionary changes. The expression patterns of the FIGN members also vary across organisms and tissues. For example, FIGNL2 shows a notably reduced expression in the mammalian nervous system compared to that in lower vertebrates. The FIGN family members have distinct roles in microtubule severing, cell division, and DNA repair. Specifically, FIGN is involved in cell division and neuronal regeneration, FIGNL1 in axonal growth and DNA repair, and FIGNL2 in cell migration and vascular development. Their involvement in these processes underscores their role as potential biomarkers for certain cancers as well as therapeutic targets for diseases affecting the nervous system and cardiovascular development. All these evolutionary insights and functional distinctions of the FIGN family offer a comprehensive framework for understanding cytoskeletal regulation and its implications in health and disease.
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Details
- Title
- Evolution and functional divergence of the Fidgetin family
- Creators
- Zhangji Dong - Nantong UniversityQing Wang - Nantong UniversityYingying Yan - Nantong UniversityLiang Oscar Qiang - Drexel UniversityMei Liu - Nantong University
- Publication Details
- Biochimica et biophysica acta. Molecular cell research, v 1872(1), 119870
- Publisher
- ELSEVIER
- Number of pages
- 10
- Grant note
- National Natural Science Foundation of China: 32070725 Major Program of The Natural Science Foundation of the Jiangsu Higher Education Institutions: 23KJA180005 Science and Technology Project of Nantong City: JC12022011 Postgraduate Research & Practice Innovation Program of Jiangsu Province: KYCX23_3384
The work was supported by the grants from the National Natural Science Foundation of China to ML (32070725) , the Major Program of The Natural Science Foundation of the Jiangsu Higher Education Institutions (23KJA180005) and funding from Science and Technology Project of Nantong City (JC12022011) to ZD, and the Postgraduate Research & Practice Innovation Program of Jiangsu Province to QW (KYCX23_3384) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001350223100001
- Scopus ID
- 2-s2.0-85207747010
- Other Identifier
- 991021933911804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology