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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Evolution of hierarchical porous structures in supramolecular guest-host hydrogels
Soft matter, v 12(37), pp 7839-7847
20 Sep 2016
PMID: 27714343
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Macromolecular interactions are used to form supramolecular assemblies, including through the interaction of guest-host chemical pairs. Microstructural heterogeneity has been observed within such physical hydrogels; yet, systematic investigation of the microstructure and its determining inputs are lacking. Herein, we investigated the hierarchical self-assembly of hyaluronic acid (HA) modified by the guest-host pair adamantane (Ad-HA, guest) and β-cyclodextrin (CD-HA, host), as well as with methacrylate groups to both tether fluorescent agents and to covalently stabilize the material structure. We observed microporous materials in the hydrated state, which temporally arose from initially homogenous hydrogels composed of the two polymers. Independent fluorescent labeling of Ad-HA and CD-HA demonstrated spatiotemporal co-localization, indicative of guest-host polymer condensation on the microscale. The hydrogel void fractions and pore diameters were independently tuned through incubation time (0-7 days), polymer concentration (1.25-10 wt%), and polymer modification (25-50% Ad-HA modification). Void fractions as great as 93.3±2.4% were achieved and pore diameters ranged from 2.1±0.5 to 1025.4±209.4 μm. The segregation of discrete solid and solute phases was measured with both atomic force microscopy and diffusive microparticle tracking analysis, where the solute phase contained only dilute polymer. The study represents a systematic investigation of hierarchical self-assembly in binary associating hydrogels, and provides insights on mechanisms that control microstructure within supramolecular hydrogels.
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Details
- Title
- Evolution of hierarchical porous structures in supramolecular guest-host hydrogels
- Creators
- Christopher B. Rodell - University of PennsylvaniaChristopher B. Highley - University of PennsylvaniaMinna H. Chen - University of PennsylvaniaNeville N. Dusaj - University of PennsylvaniaChao Wang - Drexel UniversityLin Han - Drexel UniversityJason A. Burdick - University of Pennsylvania
- Publication Details
- Soft matter, v 12(37), pp 7839-7847
- Publisher
- Royal Society of Chemistry
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000384442500014
- Scopus ID
- 2-s2.0-84988637668
- Other Identifier
- 991019168352404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Physics, Multidisciplinary
- Polymer Science