Journal article
Evolution of the Study of Methylphenidate and Its Actions on the Adult Versus Juvenile Brain
Journal of attention disorders, v 19(7), pp 603-619
Jul 2015
PMID: 22923783
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Methylphenidate (MPH) is the most often prescribed medication for treatment of ADHD. However, many of its specific cellular and molecular mechanisms of action, as well as developmental consequences of treatment, are largely unknown. This review provides an overview of current understanding of MPH efficacy, safety, and dosage in adult and pediatric ADHD patients, as well as adult animal studies and pioneering studies in juvenile animals treated with MPH.
A thorough review of the current literature on MPH efficacy and safety in children, adults, and animal models was included. Results of studies were compared and contrasted.
While MPH is currently considered safe, there is a lack of knowledge of potential developmental consequences of early treatment, as well as differences in drug actions in the developing versus mature brain system.
This review emphasizes the need for further research into the age-dependent activities and potency of MPH, and a need for tighter control and clinical relevance in future studies.
Metrics
Details
- Title
- Evolution of the Study of Methylphenidate and Its Actions on the Adult Versus Juvenile Brain
- Creators
- Kimberly R Urban - Drexel University College of Medicine, Philadelphia, PA, USAWen-Jun Gao - Drexel University College of Medicine, Philadelphia, PA, USA wgao@drexelmed.edu
- Publication Details
- Journal of attention disorders, v 19(7), pp 603-619
- Publisher
- Sage; United States
- Grant note
- MH85666 / NIMH NIH HHS R01 MH085666 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000356429800005
- Scopus ID
- 2-s2.0-84931363096
- Other Identifier
- 991014878376504721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Psychiatry
- Psychology, Developmental