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Ex Vivo Live Imaging in Brain Slices for Analysis of Neurite Formation in Combination with In Utero Electroporation
Journal article

Ex Vivo Live Imaging in Brain Slices for Analysis of Neurite Formation in Combination with In Utero Electroporation

Xiaonan Liu and Kazuhito Toyo-Oka
Methods in molecular biology (Clifton, N.J.), v 2831, pp 199-208
2024
PMID: 39134851

Abstract

Animals Brain - cytology Brain - diagnostic imaging Brain - embryology Electroporation - methods Female Mice Microscopy, Confocal - methods Neurites - metabolism Time-Lapse Imaging - methods Neurogenesis Pregnancy
The use of time-lapse live imaging enables us to track the dynamic changes in neurites during their formation. Ex vivo live imaging with acute brain slices provides a more physiological environment than cultured cells. To accomplish this, a certain method of labeling is necessary to visualize and identify neurite morphology. To understand the dynamics of neurite structure at early stages of neurite formation, we describe in this chapter ex vivo live imaging using a confocal microscope at P0 in combination with in utero electroporation (IUE).

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