Files and links (1)
SubmittedOpen Access (License Unspecified), Open
Journal article
Exactly solvable model for helix-coil-sheet transitions in protein systems
Physical review. E, Statistical, nonlinear, and soft matter physics, v 81(6), pp 061919-061919
17 Jun 2010
PMID: 20866452
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In view of the important role helix-sheet transitions play in protein aggregation, we introduce a simple model to study secondary structural transitions of helix-coil-sheet systems using a Potts model starting with an effective Hamiltonian. This energy function depends on four parameters that approximately describe entropic and enthalpic contributions to the stability of a polypeptide in helical and sheet conformations. The sheet structures involve long-range interactions between residues which are far in sequence, but are in contact in real space. Such contacts are included in the Hamiltonian. Using standard statistical mechanical techniques, the partition function is solved exactly using transfer matrices. Based on this model, we study thermodynamic properties of polypeptides, including phase transitions between helix, sheet, and coil structures.
Metrics
Details
- Title
- Exactly solvable model for helix-coil-sheet transitions in protein systems
- Creators
- John S. Schreck - Drexel UniversityJian-Min Yuan - Drexel Univ, Dept Phys, Philadelphia, PA 19104 USA
- Publication Details
- Physical review. E, Statistical, nonlinear, and soft matter physics, v 81(6), pp 061919-061919
- Publisher
- Amer Physical Soc
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000278883500002
- Scopus ID
- 2-s2.0-77953995262
- Other Identifier
- 991019168772504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Physics, Fluids & Plasmas
- Physics, Mathematical