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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression
Journal of autism and developmental disorders
09 Jun 2022
PMID: 35678944
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.
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Details
- Title
- Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression
- Creators
- Meghan E Carey - Drexel UniversityJuliette Rando - Drexel UniversityStepan Melnyk - Department of Pediatrics, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, United StatesS Jill James - Department of Pediatrics, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, United StatesNathaniel Snyder - Temple UniversityCarolyn Salafia - Department of Pathology, New York Methodist Hospital, 506 6th St, Brooklyn, NY, 11215, United StatesLisa A Croen - Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, United StatesM Daniele Fallin - A.J. Drexel Autism Institute, Drexel University, 3020 Market Street, Suite 560, Philadelphia, PA, 19104, United StatesIrva Hertz-Picciotto - Department of Public Health Sciences, University of California, 1 Shields Ave, Davis, CA, 95616, United StatesHeather Volk - Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St, Baltimore, MD, 21205, United StatesCraig Newschaffer - Pennsylvania State UniversityKristen Lyall - Drexel University
- Publication Details
- Journal of autism and developmental disorders
- Publisher
- Springer Nature
- Grant note
- R01ES016443 / NIEHS NIH HHS R24ES030893 / NIEHS NIH HHS R21HD096356 / Eunice Kennedy Shriver National Institute of Child Health and Human Development AS 5938 / Autism Speaks
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000808430000001
- Scopus ID
- 2-s2.0-85131567593
- Other Identifier
- 991019169372904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychology, Developmental