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Journal article
Executive function in young males with Klinefelter (XXY) syndrome with and without comorbid attention-deficit/hyperactivity disorder
Journal of the International Neuropsychological Society, v 17(3), pp 522-530
May 2011
PMID: 21418719
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Deficits in executive function (EF) are reported to occur in individuals with Klinefelter syndrome (XXY). The degree of impairment, if any, is variable and the nature of these deficits has not been clearly elucidated in young males. In this report, we (a) examine EF skills using multiple tasks in a non-clinic referred group of youth with XXY, (b) describe the extent of EF weaknesses in XXY when this group is compared with typical males of a similar SES or typical males with similar verbal abilities, and (c) evaluate the contribution of comorbid attention-deficit/hyperactivity disorder (ADHD) to EF skills. The sample included 27 males with XXY (ages 9-25), 27 typically developing age- and vocabulary-matched males, and 22 age- and socioeconomic status-matched males. EF tasks included Verbal Fluency, the Trail Making Test, and the CANTAB Spatial Working Memory and Stockings of Cambridge tasks. Mixed model analysis of variance was used to compare the groups on EF tasks and revealed a main effect of group but no group by task interaction. Overall, the XXY group performed less well than both control groups, but performance did not differ significantly as a function of task. ADHD comorbidity in males with XXY was related to poorer EF skills.
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Details
- Title
- Executive function in young males with Klinefelter (XXY) syndrome with and without comorbid attention-deficit/hyperactivity disorder
- Creators
- Nancy Raitano Lee - National Institute of Mental HealthGregory L Wallace - National Institute of Mental HealthLiv S Clasen - National Institute of Mental HealthRhoshel K Lenroot - National Institute of Mental HealthJonathan D Blumenthal - National Institute of Mental HealthSamantha L White - National Institute of Mental HealthMark J Celano - National Institute of Mental HealthJay N Giedd - National Institute of Mental Health
- Publication Details
- Journal of the International Neuropsychological Society, v 17(3), pp 522-530
- Publisher
- Cambridge University Press
- Grant note
- Z99 MH999999 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000290103600014
- Scopus ID
- 2-s2.0-79956133390
- Other Identifier
- 991019296720004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
- Psychology