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Journal article
Exercise-Induced Plasticity in Signaling Pathways Involved in Motor Recovery after Spinal Cord Injury
International journal of molecular sciences, v 22(9), p4858
01 May 2021
PMID: 34064332
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal cord injury (SCI) leads to numerous chronic and debilitating functional deficits that greatly affect quality of life. While many pharmacological interventions have been explored, the current unsurpassed therapy for most SCI sequalae is exercise. Exercise has an expansive influence on peripheral health and function, and by activating the relevant neural pathways, exercise also ameliorates numerous disorders of the central nervous system (CNS). While the exact mechanisms by which this occurs are still being delineated, major strides have been made in the past decade to understand the molecular underpinnings of this essential treatment. Exercise rapidly and prominently affects dendritic sprouting, synaptic connections, neurotransmitter production and regulation, and ionic homeostasis, with recent literature implicating an exercise-induced increase in neurotrophins as the cornerstone that binds many of these effects together. The field encompasses vast complexity, and as the data accumulate, disentangling these molecular pathways and how they interact will facilitate the optimization of intervention strategies and improve quality of life for individuals affected by SCI. This review describes the known molecular effects of exercise and how they alter the CNS to pacify the injury environment, increase neuronal survival and regeneration, restore normal neural excitability, create new functional circuits, and ultimately improve motor function following SCI.
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Details
- Title
- Exercise-Induced Plasticity in Signaling Pathways Involved in Motor Recovery after Spinal Cord Injury
- Creators
- Jadwiga N. Bilchak - Drexel UniversityGuillaume Caron - Drexel UniversityMarie-Pascale Cote - Drexel University
- Publication Details
- International journal of molecular sciences, v 22(9), p4858
- Publisher
- Mdpi
- Number of pages
- 19
- Grant note
- NS083666; NS119475 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 647897 / Craig H. Neilsen Foundation SC190008 / Department of Defense; United States Department of Defense
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000650434600001
- Scopus ID
- 2-s2.0-85105176161
- Other Identifier
- 991019168718204721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary