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Journal article
Exercise after spinal cord injury as an agent for neuroprotection, regeneration and rehabilitation
Brain research, v 1619
04 Sep 2015
PMID: 25866284
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal cord injury (SCI) is a traumatic event from which there is limited recovery of function, despite the best efforts of many investigators to devise realistic therapeutic treatments. Partly this is due to the multifaceted nature of SCI, where there is considerable disarray and dysfunction secondary to the initial injury. Contributing to this secondary degeneration is neurotoxicity, vascular dysfunction, glial scarring, neuroinflammation, apoptosis and demyelination. It seems logical that addressing the need for neuroprotection, regeneration and rehabilitation will require different treatment strategies that may be applied at varied stages of the post-injury response. Here we focus on a single strategy, exercise/physical training, which appears to have multiple applications and benefits for an acute or chronic SCI. Exercise has been demonstrated to be advantageous at cellular and biochemical levels, as well as being of benefit for the whole animal or human subject. Data from our lab and others will be discussed to further elucidate the many positive aspects of implementing exercise following injury and to suggest that rehabilitation is not the sole target of a training regimen following SCI. This article is part of a Special Issue entitled SI: Spinal cord injury.
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Details
- Title
- Exercise after spinal cord injury as an agent for neuroprotection, regeneration and rehabilitation
- Creators
- Harra R Sandrow-Feinberg - Drexel UniversityJohn D Houlé - Drexel University
- Publication Details
- Brain research, v 1619
- Publisher
- Elsevier
- Grant note
- R37 NS026380 / NINDS NIH HHS R01 NS026380 / NINDS NIH HHS NS026380 / NINDS NIH HHS P01 NS055976 / NINDS NIH HHS NS055976 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000360776000002
- Scopus ID
- 2-s2.0-84961131607
- Other Identifier
- 991019168952304721
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- Web of Science research areas
- Neurosciences