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Journal article
Exercise following a Short Immobilization Period Is Detrimental to Tendon Properties and Joint Mechanics in a Rat Rotator Cuff Injury Model
Journal of orthopaedic research, v 28(7), pp 841-845
01 Jul 2010
PMID: 20058271
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rotator cuff tears are a common clinical problem that can result in pain and disability. Previous studies in a rat model showed enhanced tendon to bone healing with postoperative immobilization. The objective of this study was to determine the effect of postimmobilization activity level on insertion site properties and joint mechanics in a rat model. Our hypothesis was that exercise following a short period of immobilization will cause detrimental changes in insertion site properties compared to cage activity following the same period of immobilization, hut that passive shoulder mechanics will not be affected. We detached and repaired the supraspinatus tendon of 22 Sprague-Dawley rats, and the injured shoulder was immobilized postoperatively for 2 weeks. Following immobilization, rats were prescribed cage activity or exercise for 12 weeks. Passive shoulder mechanics were determined, and following euthansia, tendon cross-sectional area and mechanical properties were measured. Exercise following immobilization resulted in significant decreases compared to cage activity in range of motion, tendon stiffness, modulus, percent relaxation, and several parameters from both a structurally based elastic model and a quasi-linear viscoelastic model. Therefore, we conclude that after a short period of immobilization, increased activity is detrimental to both tendon mechanical properties and shoulder joint mechanics, presumably due to increased scar production. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:841-845, 2010
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Details
- Title
- Exercise following a Short Immobilization Period Is Detrimental to Tendon Properties and Joint Mechanics in a Rat Rotator Cuff Injury Model
- Creators
- Cathryn D. Peltz - University of PennsylvaniaJoseph J. Sarver - University of PennsylvaniaLeAnn M. Dourte - University of PennsylvaniaCarola C. Wuergler-Hauri - University of ZurichGerald R. Williams - Thomas Jefferson UniversityLouis J. Soslowsky - University of Pennsylvania
- Publication Details
- Journal of orthopaedic research, v 28(7), pp 841-845
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- NIH/NIAMS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) NSF; National Science Foundation (NSF) P30AR050950 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000278654500001
- Scopus ID
- 2-s2.0-77953196128
- Other Identifier
- 991019323666504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Orthopedics