Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease
The Neuroscientist (Baltimore, Md.), v 24(2), pp 111-129
01 Apr 2018
PMID: 28593814
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intra-axonal protein synthesis has been shown to play critical roles in both development and repair of axons. Axons provide long-range connectivity in the nervous system, and disruption of their function and/or structure is seen in several neurological diseases and disorders. Axonally synthesized proteins or losses in axonally synthesized proteins contribute to neurodegenerative diseases, neuropathic pain, viral transport, and survival of axons. Increasing sensitivity of RNA detection and quantitation coupled with methods to isolate axons to purity has shown that a surprisingly complex transcriptome exists in axons. This extends across different species, neuronal populations, and physiological conditions. These studies have helped define the repertoire of neuronal mRNAs that can localize into axons and imply previously unrecognized functions for local translation in neurons. Here, we review the current state of transcriptomics studies of isolated axons, contrast axonal mRNA profiles between different neuronal types and growth states, and discuss how mRNA transport into and translation within axons contribute to neurological disorders.
Metrics
Details
- Title
- Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease
- Creators
- Amar N. Kar - Univ South Carolina, Dept Biol Sci, 715 Sumter St,CLS 401, Columbia, SC 29208 USASeung Joon Lee - University of South CarolinaJeffery L. Twiss - Drexel University
- Publication Details
- The Neuroscientist (Baltimore, Md.), v 24(2), pp 111-129
- Publisher
- Sage
- Number of pages
- 19
- Grant note
- W81XWH-2013-1-308 / Department of Defense/US Army Congressionally Mandated Research Program R01NS041596 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01-NS041596; R01-NS086993; P01-NS055976 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Dr Miriam and Sheldon G. Adelson Medical Research Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000429962600007
- Scopus ID
- 2-s2.0-85043712312
- Other Identifier
- 991021892106604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences