Journal article
Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management
Acta neurochirurgica, v 153(12), pp 2293-2306
01 Dec 2011
PMID: 21976235
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The indications for deep brain stimulation (DBS) are expanding, and the feasibility and efficacy of this surgical procedure in various neurologic and neuropsychiatric disorders continue to be tested. This review attempts to provide background and rationale for applying this therapeutic option to obesity and addiction. We review neural targets currently under clinical investigation for DBS—the hypothalamus and nucleus accumbens—in conditions such as cluster headache and obsessive-compulsive disorder. These brain regions have also been strongly implicated in obesity and addiction. These disorders are frequently refractory, with very high rates of weight regain or relapse, respectively, despite the best available treatments.
We performed a structured literature review of the animal studies of DBS, which revealed attenuation of food intake, increased metabolism, or decreased drug seeking. We also review the available radiologic evidence in humans, implicating the hypothalamus and nucleus in obesity and addiction.
The available evidence of the promise of DBS in these conditions combined with significant medical need, support pursuing pilot studies and clinical trials of DBS in order to decrease the risk of dietary and drug relapse.
Well-designed pilot studies and clinical trials enrolling carefully selected patients with obesity or addiction should be initiated.
Metrics
Details
- Title
- Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management
- Creators
- Casey H Halpern - Hospital of the University of PennsylvaniaNapoleon Torres - ClinatecHoward I Hurtig - Hospital of the University of PennsylvaniaJohn A Wolf - Hospital of the University of PennsylvaniaJames Stephen - Hospital of the University of PennsylvaniaMichael Y Oh - Allegheny General HospitalNoel N Williams - Hospital of the University of PennsylvaniaMarc A Dichter - Hospital of the University of PennsylvaniaJurg L Jaggi - Hospital of the University of PennsylvaniaArthur L Caplan - Hospital of the University of PennsylvaniaKyle M Kampman - Hospital of the University of PennsylvaniaThomas A Wadden - Hospital of the University of PennsylvaniaDonald M Whiting - Allegheny General HospitalGordon H Baltuch - Hospital of the University of Pennsylvania
- Publication Details
- Acta neurochirurgica, v 153(12), pp 2293-2306
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:000297159700001
- Scopus ID
- 2-s2.0-83055181161
- Other Identifier
- 991021448163904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery