Journal article
Experience with a six-month regimen of Pneumocystis pneumonia prophylaxis in 122 HIV-positive kidney transplant recipients
Transplant infectious disease, v 23(3), pp e13511-n/a
01 Jun 2021
PMID: 33217136
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Anti-Pneumocystis pneumonia (PCP) prophylaxis is recommended for 3 to 6 months post-transplant in HIV-negative kidney transplant recipients. For HIV-positive kidney transplant recipients, there is no definite duration of primary prophylaxis and is often prescribed life-long. The objective of this study was to determine the incidence of PCP in HIV-positive recipients who received 6 months of prophylaxis with trimethoprim-sulfamethoxazole or an alternative agent. One hundred and twenty-two HIV-positive recipients received a kidney transplant from 2001 to 2017 at Hahnemann University Hospital. Most patients received induction immunosuppression with an IL-2 receptor antagonist, with or without intravenous immunoglobulin. Only one patient received anti-thymocyte globulin. Maintenance immunosuppression included a calcineurin-inhibitor (tacrolimus or cyclosporine), an antiproliferative agent (mycophenolate or sirolimus), and prednisone. Mean CD4 cell count was 461 +/- 127 cells/uL prior to transplant and 463 +/- 229 cells/mu L at 6 to 12 months after transplant. None of the recipients developed PCP after a median follow-up of 2.88 years (IQR 1.16-4.87). Based on our observation, a 6-month regimen of PCP prophylaxis may be sufficient among HIV-positive recipients, similar to those without HIV infection.
Metrics
Details
- Title
- Experience with a six-month regimen of Pneumocystis pneumonia prophylaxis in 122 HIV-positive kidney transplant recipients
- Creators
- Christina D. Mejia - Johns Hopkins Univ, Div Nephrol, 1830 Bldg,Suite 416, Baltimore, MD 21287 USAGregory E. Malat - Hospital of the University of PennsylvaniaSuzanne M. Boyle - Temple UniversityKarthik Ranganna - Drexel UniversityDong Heun Lee - University of California, San Francisco
- Publication Details
- Transplant infectious disease, v 23(3), pp e13511-n/a
- Publisher
- Wiley
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); College of Medicine; Surgery
- Web of Science ID
- WOS:000595097100001
- Scopus ID
- 2-s2.0-85097005663
- Other Identifier
- 991019168337504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Transplantation