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Experimental Biomechanics of Neonatal Brachial Plexus Avulsion Injuries Using a Piglet Model
Journal article   Open access   Peer reviewed

Experimental Biomechanics of Neonatal Brachial Plexus Avulsion Injuries Using a Piglet Model

Sriram Balasubramanian, Anita Singh, Kalyani Ghuge and Yashvy Patni
Bioengineering, v 12(1), 91
20 Jan 2025
DOI: https://doi.org/10.3390/bioengineering12010091
PMID: 39851365
Featured in Collection :   Research Supported by Drexel Libraries' OA Programs
url
https://doi.org/10.3390/bioengineering12010091View
Published, Version of Record (VoR)Open Access Discount via Drexel Libraries Read and Publish Program 2025CC BY V4.0,  Open

Abstract

avulsion neonatal brachial plexus strain load stretch palsy birthing Biomechanics Neonatal Disorders
Background: A brachial plexus avulsion occurs when the nerve root separates from the spinal cord during birthing trauma, such as shoulder dystocia or a difficult vaginal delivery. A complete paralysis of the affected levels occurs post-brachial plexus avulsion. Despite being reported in 10–20% of brachial plexus birthing injuries, it remains poorly diagnosed during the acute stages of injury, leading to poor intervention approaches. The poor diagnosis of brachial plexus avulsion injury can be attributed to the currently unavailable biomechanics of brachial plexus avulsion. While the biomechanical properties of neonatal brachial plexus are available, the forces required to avulse a neonatal brachial plexus remain unknown. Methods: This study aims to provide detailed biomechanics of the required forces and corresponding strains for neonatal brachial plexus avulsion. Biomechanical tensile testing was performed on an isolated, clinically relevant piglet spinal cord and brachial plexus complex, and the required avulsion forces and strains were measured. Results: The reported failure forces and corresponding strains were 3.9 ± 1.6 N at a 27.9 ± 6.5% strain, respectively. Conclusion: The obtained data are required to understand the avulsion injury biomechanics and provide the necessary experimental data for computational model development that serves as an ideal surrogate for understanding complicated birthing injuries in newborns.

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Collaboration types
Domestic collaboration
Web of Science research areas
Biotechnology & Applied Microbiology
Engineering, Biomedical
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