Journal article
Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
ELIFE, v 10, e73430
07 Dec 2021
PMID: 34874009
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
As part of the Reproducibility Project: Cancer Biology, we published Registered Reports that described how we intended to replicate selected experiments from 29 high-impact preclinical cancer biology papers published between 2010 and 2012. Replication experiments were completed and Replication Studies reporting the results were submitted for 18 papers, of which 17 were accepted and published by eLife with the rejected paper posted as a preprint. Here, we report the status and outcomes obtained for the remaining 11 papers. Four papers initiated experimental work but were stopped without any experimental outcomes. Two papers resulted in incomplete outcomes due to unanticipated challenges when conducting the experiments. For the remaining five papers only some of the experiments were completed with the other experiments incomplete due to mundane technical or unanticipated methodological challenges. The experiments from these papers, along with the other experiments attempted as part of the Reproducibility Project: Cancer Biology, provides evidence about the challenges of repeating preclinical cancer biology experiments and the replicability of the completed experiments.
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Details
- Title
- Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
- Publication Details
- ELIFE, v 10, e73430
- Publisher
- eLIFE SCIENCES PUBL LTD; CAMBRIDGE
- Grant note
- The Reproducibility Project: Cancer Biology was supported by a grant from Arnold Ventures (formerly known as the Laura and John Arnold Foundation) provided to the Center for Open Science in collaboration with Science Exchange. The funder had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000730077000001
- Scopus ID
- 2-s2.0-85121387008
- Other Identifier
- 991021860751004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology