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Journal article
Expert Panel Workshop Consensus Statement on the Role of the Environment in the Development of Autoimmune Disease
International journal of molecular sciences, v 15(8), pp 14269-14297
01 Aug 2014
PMID: 25196523
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autoimmune diseases include 80 or more complex disorders characterized by self-reactive, pathologic immune responses in which genetic susceptibility is largely insufficient to determine disease onset. In September 2010, the National Institute of Environmental Health Sciences (NIEHS) organized an expert panel workshop to evaluate the role of environmental factors in autoimmune diseases, and the state of the science regarding relevant mechanisms, animal models, and human studies. The objective of the workshop was to analyze the existing data to identify conclusions that could be drawn regarding environmental exposures and autoimmunity and to identify critical knowledge gaps and areas of uncertainty for future study. This consensus document summarizes key findings from published workshop monographs on areas in which "confident" and "likely" assessments were made, with recommendations for further research. Transcribed notes and slides were reviewed to synthesize an overview on exposure assessment and questions addressed by interdisciplinary panels. Critical advances in the field of autoimmune disease research have been made in the past decade. Collaborative translational and interdisciplinary research is needed to elucidate the role of environmental factors in autoimmune diseases. A focus on exposure assessment methodology is needed to improve the effectiveness of human studies, and more experimental studies are needed to focus on causal mechanisms underlying observed associations of environmental factors with autoimmune disease in humans.
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Details
- Title
- Expert Panel Workshop Consensus Statement on the Role of the Environment in the Development of Autoimmune Disease
- Creators
- Christine G. Parks - National Institutes of HealthFrederick W. Miller - National Institutes of HealthKenneth Michael Pollard - Scripps Research InstituteCarlo Selmi - University of California, DavisDori Germolec - National Institutes of HealthKelly Joyce - Drexel UniversityNoel R. Rose - BloombergMichael C. Humble - National Institutes of Health
- Publication Details
- International journal of molecular sciences, v 15(8), pp 14269-14297
- Publisher
- Mdpi
- Number of pages
- 29
- Grant note
- Z01ES049028 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) Z01 ES049028 / Intramural Research Program of the NIH, National Institute of Environmental Health Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Sociology
- Web of Science ID
- WOS:000341519600067
- Scopus ID
- 2-s2.0-84922374858
- Other Identifier
- 991019168718904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary