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Exploring the Unknown: Appreciating the Challenges of Non-compaction Cardiomyopathy
Journal article   Open access   Peer reviewed

Exploring the Unknown: Appreciating the Challenges of Non-compaction Cardiomyopathy

Muhammad Ibraiz Bilal, Fawwad A. Ansari, Muhammad Umer Riaz Gondal, Mubashira Aftab, Abdul Moiz Qureshi and Hayah Kassis-George
Curēus (Palo Alto, CA), v 16(5), 61142
26 May 2024
DOI: https://doi.org/10.7759/cureus.61142
PMID: 38933642
url
https://doi.org/10.7759/cureus.61142View
Published, Version of Record (VoR) Open

Abstract

General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Science & Technology
Left ventricular non -compaction cardiomyopathy (LVNC), or non -compaction cardiomyopathy (NCCM), is defined by pronounced left ventricular trabeculations and deep intertrabecular recesses connecting with the ventricular cavity. Patients with NCCM can be asymptomatic or have severe complications, including heart failure, arrhythmias, thromboembolism, and sudden cardiac death. Our case discusses a patient with shortness of breath who was found to have a newly decreased ejection fraction. The workup revealed nonischemic cardiomyopathy and cardiac MRI showed hyper-trabeculations consistent with NCCM. The patient was started on oral anticoagulation and guideline -directed medical therapy (GDMT) and discharged with an event monitor. NCCM stands as a relatively rare and enigmatic condition, often veiled in ambiguity. The absence of standardized diagnostic and management protocols further complicates its clinical landscape. While echocardiography is the primary diagnostic tool, its tendency for under -diagnosis poses a significant challenge. Conversely, advanced imaging modalities like cardiac MRI may lead to instances of overdiagnosis. Treatment approaches are non-specific, incorporating GDMT, anticoagulation, implantable cardioverterdefibrillator placement, and genetic testing paired with counseling. Prioritizing genetic research is crucial to uncover tailored therapeutic interventions. Establishing consensus guidelines and refining diagnostic accuracy are pivotal steps toward mitigating the risks associated with under and over -diagnosis.

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