Journal article
Exploring the complexity of amyloid-beta fibrils: structural polymorphisms and molecular interactions
Biochemical Society transactions
19 Jul 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The aggregation of amyloid-beta (Aβ) peptides into cross-β structures forms a variety of distinct fibril conformations, potentially correlating with variations in neurodegenerative disease progression. Recent advances in techniques such as X-ray crystallography, solid-state NMR, and cryo-electron microscopy have enabled the development of high-resolution molecular structures of these polymorphic amyloid fibrils, which are either grown in vitro or isolated from human and transgenic mouse brain tissues. This article reviews our current understanding of the structural polymorphisms in amyloid fibrils formed by Aβ40 and Aβ42, as well as disease-associated mutants of Aβ peptides. The aim is to enhance our understanding of various molecular interactions, including hydrophobic and ionic interactions, within and among cross-β structures.The aggregation of amyloid-beta (Aβ) peptides into cross-β structures forms a variety of distinct fibril conformations, potentially correlating with variations in neurodegenerative disease progression. Recent advances in techniques such as X-ray crystallography, solid-state NMR, and cryo-electron microscopy have enabled the development of high-resolution molecular structures of these polymorphic amyloid fibrils, which are either grown in vitro or isolated from human and transgenic mouse brain tissues. This article reviews our current understanding of the structural polymorphisms in amyloid fibrils formed by Aβ40 and Aβ42, as well as disease-associated mutants of Aβ peptides. The aim is to enhance our understanding of various molecular interactions, including hydrophobic and ionic interactions, within and among cross-β structures.
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Details
- Title
- Exploring the complexity of amyloid-beta fibrils: structural polymorphisms and molecular interactions
- Creators
- Yoongyeong Baek - Drexel UniversityMyungwoon Lee - Drexel University
- Publication Details
- Biochemical Society transactions
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:001275306100001
- Scopus ID
- 2-s2.0-85202790655
- Other Identifier
- 991021894606904721
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- Web of Science research areas
- Biochemistry & Molecular Biology