Journal article
Exploring the mechanical strength, antimicrobial performance, and bioactivity of 3D-printed silicon nitride-PEEK composites in cervical spinal cages
International journal of bioprinting, v 10(2), pp 431-444
01 Jan 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this study, our goal was to assess the suitability of a polyether-ether-ketone (PEEK) and silicon nitride (Si 3 N 4 ) polymer composite for antimicrobial three-dimensional (3D) -printed cervical cages. Generic cage designs (PEEK and 15 vol.% Si 3 N & aacute; PEEK) were 3D -printed, including solid and porous cage designs. Cages were tested in static compression, compression shear, and torsion per ASTM F2077. For antibacterial testing, virgin and composite filament samples were inoculated with Staphylococcus epidermidis and Escherichia coli . In vitro cell testing was conducted using MC3T3-E1 mouse preosteoblasts, where cell proliferation, cumulative mineralization, and osteogenic activity were measured. The 3D -printed PEEK and Si 3 N & aacute; PEEK cages exhibited adequate mechanical strength for all designs, exceeding 14.7 kN in compression and 6.9 kN in compression shear. Si 3 N & aacute; PEEK exhibited significantly lower bacterial adhesion levels, with a 93.9% reduction (1.21 log), and enhanced cell proliferation when compared to PEEK. Si 3 N & aacute; PEEK would allow for custom fabrication of 3D -printed spinal implants that reduce the risk of infection compared to unfilled PEEK or metallic alloys.
Metrics
10 Record Views
Details
- Title
- Exploring the mechanical strength, antimicrobial performance, and bioactivity of 3D-printed silicon nitride-PEEK composites in cervical spinal cages
- Creators
- Cemile Basgul - Drexel University, School of Biomedical Engineering, Science, and Health SystemsPaul Desantis - Drexel UniversityTabitha Derr - Drexel University, Graduate School of Biomedical Sciences and Professional StudiesNoreen J. Hickok - Thomas Jefferson UniversityRyan M. Bock - SINTX Technol Inc, Salt Lake City, UT USASteven M. Kurtz - Drexel University, School of Biomedical Engineering, Science, and Health Systems
- Publication Details
- International journal of bioprinting, v 10(2), pp 431-444
- Publisher
- Access science Publishing
- Number of pages
- 14
- Grant note
- R41GM146268 / National Institute of General Medical Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Graduate School of Biomedical Sciences and Professional Studies; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001233880100029
- Scopus ID
- 2-s2.0-85194970160
- Other Identifier
- 991022064140104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials