Journal article
Exploring the relationship between gut microbiome modulation and blood pressure in type 2 diabetes: An umbrella review
Nutrition, metabolism, and cardiovascular diseases, v 34(9), pp 2046-2054
01 Sep 2024
PMID: 38902190
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aims: Given the epidemic proportions of type 2 diabetes mellitus (T2DM) globally, it's crucial to comprehensively understand the factors influencing its management. The gut microbiome, known for its influence on various aspects of health, has emerged as a potential regulator of blood pressure in individuals with T2DM. This umbrella review aimed to consolidate the findings of existing meta-analyses investigating the impact of gut microbiome modulation on systolic and diastolic blood pressure in T2DM patients. Data synthesis: Adhering to the Preferred Reporting Items for Systematic Reviews and Metaanalyses (PRISMA) guidelines, we systematically searched PubMed, Scopus, and Web of Science databases from inception to July 2023. Quality assessment was performed using the AMSTAR2 and GRADE checklists. Statistical analyses were conducted using Comprehensive Meta-Analysis (CMA) version 3. A total of 6 meta-analyses meeting the inclusion criteria were included. The results revealed a significant association between microbial modulation and diastolic blood pressure (SMD: -0.133; 95% CI: -0.219 to -0.048; P = 0.002). However, the effect of gut microbial modulation on systolic blood pressure did not reach statistical significance (SMD: -0.077; 95% CI: -0.162 to 0.009; P = 0.078). Conclusion: This study found that modulating the gut microbiome had a statistically significant impact on diastolic blood pressure in individuals with type 2 diabetes mellitus (T2DM). However, no significant effect was observed on systolic blood pressure. While high-quality meta-analyses reported favorable outcomes, caution is warranted due to the low clinical importance, diversity in study populations, and variations in interventions.
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Details
- Title
- Exploring the relationship between gut microbiome modulation and blood pressure in type 2 diabetes: An umbrella review
- Creators
- Ehsan Amini-Salehi - Guilan University of Medical SciencesAbinash Mahapatro - Hi-Tech Medical College & HospitalRohan Reddy Korsapati - University of ToledoAishwarya Reddy Korsapati - University of BuckinghamShika M. Jain - MVJ Medical College and Research HospitalAli Babaeizad - Semnan University of Medical SciencesSina Mohammadi - Semnan University of Medical SciencesPegah Rashidian - Guilan University of Medical SciencesMohammad Hashemi - Hormozgan University of Medical SciencesTirth Dave - Bukovinian State Medical UniversityParsa Jamilian - Keele UniversitySoheil Hassanipour - Guilan University of Medical SciencesMohammad-Hossein Keivanlou - College Station Medical CenterDhruvan Patel - Drexel University
- Publication Details
- Nutrition, metabolism, and cardiovascular diseases, v 34(9), pp 2046-2054
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001287727200001
- Scopus ID
- 2-s2.0-85196354446
- Other Identifier
- 991022202114004721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Endocrinology & Metabolism
- Nutrition & Dietetics