Journal article
Exposure to Phenols, Phthalates, and Parabens and Development of Metabolic Syndrome Among Mexican Women in Midlife
Frontiers in public health, v 9, pp 620769-620769
2021
PMID: 33718320
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evidence suggests exposure to endocrine-disrupting chemicals (EDCs) can influence Metabolic Syndrome (MetS) risk in adults, but it is unclear if EDCs impact women during midlife. We examined if EDCs measured in adult women were predictive of MetS and its components 9 years later.
We measured urinary phthalate metabolites, phenols, and parabens collected in 2008 among 73 females from the ELEMENT study. MetS and its components (Abdominal Obesity, Hypertriglyceridemia, Cholesterolemia, Hypertension, and Hyperglycemia) were assessed in 2017. We regressed log-transformed EDC concentrations on MetS and MetS components using logistic regression, adjusting for age and physical activity.
At follow-up, the mean (SD) age was 46.6 (6.3) years; the prevalence of MetS was 34.3%. Sum of dibutyl phthalate metabolites (ΣDBP), monobenzyl phthalate (MBzP), and monoethyl phthalate (MEP) were associated with an increased odds of hypertriglyceridemia. 2,5-dichlorophenol (2,5 DCP) and 2,4-dichlorophenol (2,4 DCP) were associated with increased odds of hypertriglyceridemia. The odds of hypertension were 4.18 (95% CI: 0.98, 17.7,
< 0.10) and 3.77 (95% CI: 0.76, 18.62,
< 0.10) times higher for every IQR increase in MCOP and propyl paraben, respectively. The odds of hyperglycemia were 0.46 (95% CI: 0.18, 1.17
< 0.10) times lower for every IQR increase in the sum of di-2-ethylhexyl phthalate metabolites (ΣDEHP), and the odds of abdominal obesity were 0.70 (95% CI: 0.40, 1.21,
< 0.10) lower for every IQR increase in the concentration of triclosan.
We found EDCs measured in 2008 were marginally predictive of hypertriglyceridemia and hypertension 9 years later. Results suggest that lower exposure to certain toxicants was related to lower markers of metabolic risk among midlife women.
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Details
- Title
- Exposure to Phenols, Phthalates, and Parabens and Development of Metabolic Syndrome Among Mexican Women in Midlife
- Creators
- Astrid N Zamora - University of MichiganErica C Jansen - University of MichiganMarcela Tamayo-Ortiz - Mexican Social Security InstituteJaclyn M Goodrich - University of MichiganBrisa N Sánchez - Drexel UniversityDeborah J Watkins - University of MichiganJuan Alfredo Tamayo-Orozco - Universidad AnáhuacMartha M Téllez-Rojo - National Institute of Public Health, Mexico City, Mexico.Adriana Mercado-García - National Institute of Public Health, Mexico City, Mexico.Ana Baylin - University of MichiganJohn D Meeker - University of MichiganKaren E Peterson - University of Michigan
- Publication Details
- Frontiers in public health, v 9, pp 620769-620769
- Publisher
- Frontiers
- Grant note
- P30 DK020572 / NIDDK NIH HHS K01 HL151673 / NHLBI NIH HHS P01 ES022844 / NIEHS NIH HHS R24 ES028502 / NIEHS NIH HHS P30 ES017885 / NIEHS NIH HHS P30 DK089503 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000627761900001
- Scopus ID
- 2-s2.0-85102434057
- Other Identifier
- 991020100079204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health