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Journal article
Exposure to Traffic and Early Life Respiratory Infection: A Cohort Study
Pediatric pulmonology, v 50(3), pp 252-259
Mar 2015
PMID: 24678045
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined whether proximity to a major roadway and traffic density around the home during pregnancy are associated with risk of early life respiratory infection in a pre-birth cohort in the Boston area. We geocoded addresses for 1,263 mother-child pairs enrolled during the first trimester of pregnancy in Project Viva during 1999-2002. We calculated distance from home to nearest major roadway and traffic density in a 100m buffer around the home. We defined respiratory infection as maternal report of 1 doctor-diagnosed pneumonia, bronchiolitis, croup, or other respiratory infection from birth until the early childhood visit (median age 3.3). We used relative risk regression models adjusting for potential confounders to estimate associations between traffic exposures and risk of respiratory infection. Distance to roadway during pregnancy was associated with risk of respiratory infection. In fully adjusted models, relative risks (95% CI) for respiratory infection were: 1.30 (1.08, 1.55) for <100m, 1.15 (0.93, 1.41) for 100 to <200m, and 0.95 (0.84, 1.07) for 200 to <1,000m compared with living 1,000m away from a major roadway. Each interquartile range increase in distance to roadway was associated with an 8% (95% CI 0.87, 0.98) lower risk, and each interquartile range increase in traffic density was associated with a 5% (95% CI 0.98, 1.13) higher risk of respiratory infection. Our findings suggest that living close to a major roadway during pregnancy may predispose the developing lung to infection in early life. Pediatr Pulmonol. 2015; 50:252-259. (c) 2014 Wiley Periodicals, Inc.
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Details
- Title
- Exposure to Traffic and Early Life Respiratory Infection: A Cohort Study
- Creators
- Mary B. Rice - Massachusetts General HospitalSheryl L. Rifas-Shiman - Harvard UniversityEmily Oken - Harvard Pilgrim Health CareMatthew W. Gillman - Harvard Pilgrim Health CarePetter L. Ljungman - Beth Israel Deaconess Medical CenterAugusto A. Litonjua - Brigham and Women's HospitalJoel Schwartz - Harvard UniversityBrent A. Coull - Harvard UniversityAntonella Zanobetti - Harvard UniversityPetros Koutrakis - Harvard UniversitySteven J. Melly - Harvard UniversityMurray A. Mittleman - Beth Israel Deaconess Medical CenterDiane R. Gold - Brigham and Women's Hospital
- Publication Details
- Pediatric pulmonology, v 50(3), pp 252-259
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- R01AI102960 / NIH/NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) 1F32ES023352-01; P30ES000002; P01-ES009825 / NIH/NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) K24 HD069408 / NIH/NICHD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R832416; RD834798 / US EPA; United States Environmental Protection Agency 5T32HL007374 / NIH/NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R832416; 909117 / EPA; United States Environmental Protection Agency
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000349997700007
- Scopus ID
- 2-s2.0-84923136064
- Other Identifier
- 991021875345504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics
- Respiratory System