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Journal article
Exposure to Traffic and Left Ventricular Mass and Function The Multi-Ethnic Study of Atherosclerosis
American journal of respiratory and critical care medicine, v 179(9), pp 827-834
01 May 2009
PMID: 19164703
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Abstract
Rationale: Ambient air pollution has been associated with heart failure morbidity and mortality. The mechanisms responsible for these associations are unknown but may include the effects of traffic-related pollutants on vascular or autonomic function.
Objectives: We assessed the cross-sectional relation between long-term air pollution, traffic exposures, and important end-organ measures of alterations in cardiac function-left ventricular mass index (LVMI) and ejection fraction-in the Multi-Ethnic Study of Atherosclerosis, a multicenter study of adults without previous clinical cardiovascular disease.
Methods: A total of 3,827 eligible participants (aged 45-84 yr) underwent cardiac magnetic resonance imaging between 2000 and 2002. We estimated air pollution exposures using residential proximity to major roadways and interpolated concentrations of fine particulate matter (less than 2.5 microns in diameter). We examined adjusted associations between these exposures and left ventricular mass and function.
Measurements and Main Results: Relative to participants living more than 150 m from a major roadway, participants living within 50 m of a major roadway showed an adjusted 1.4 g/m(2) (95% CI, 0.3-2.5) higher LVMl, a difference in mass corresponding to a 5.6 mm Hg greater systolic blood pressure. Ejection fraction was not associated with proximity to major roadways. Limited variability in estimates of fine particulate matter was observed within cities, and no associations with particulate matter were found for either outcome after adjustment for center.
Conclusions: Living in close proximity to major roadways is associated with higher LVMI, suggesting chronic vascular end-organ damage from a traffic-related environmental exposure. Air pollutants or another component of roadway proximity, such as noise, could be responsible.
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Details
- Title
- Exposure to Traffic and Left Ventricular Mass and Function The Multi-Ethnic Study of Atherosclerosis
- Creators
- Victor C. Van Hee - University of WashingtonSara D. Adar - University of WashingtonAdam A. Szpiro - University of WashingtonR. Graham Barr - Columbia UniversityDavid A. Bluemke - Johns Hopkins UniversityAna V. Diez Roux - University of MichiganEdward A. Gill - University of WashingtonLianne Sheppard - University of WashingtonJoel D. Kaufman - University of Washington
- Publication Details
- American journal of respiratory and critical care medicine, v 179(9), pp 827-834
- Publisher
- American Thoracic Society
- Number of pages
- 8
- Grant note
- N01HC095159 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) K24ES013195 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01-HC-95159; N01-HC-95165; N01-HC-95169 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) RD831697 / U.S. Environmental Protection Agency STAR; United States Environmental Protection Agency ZIAEB000065 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000265665000012
- Scopus ID
- 2-s2.0-65549086490
- Other Identifier
- 991020112278704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine
- Respiratory System