Logo image
Back
Exposure to Violence and Virologic and Immunological Outcomes Among Youth With Perinatal HIV in the Pediatric HIV/AIDS Cohort Study
Journal article   Open access   Peer reviewed

Exposure to Violence and Virologic and Immunological Outcomes Among Youth With Perinatal HIV in the Pediatric HIV/AIDS Cohort Study

Deborah Kacanek, Kathleen Malee, Claude A Mellins, Katherine Tassiopoulos, Renee Smith, Mitzie Grant, Sonia Lee, Danish Q Siddiqui and Ana Puga
Journal of adolescent health, v 59(1), pp 30-37
Jul 2016
DOI: https://doi.org/10.1016/j.jadohealth.2016.03.004
PMID: 27089837
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc4920719View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Adolescent Caregivers - statistics & numerical data Child Cohort Studies Crime Victims - statistics & numerical data Domestic Violence Exposure to Violence - statistics & numerical data Female HIV Infections - psychology HIV Infections - virology Humans Logistic Models Male Odds Ratio Self Report Sex Offenses - statistics & numerical data Viral Load - genetics
Exposure to violence in childhood has been linked to adverse health outcomes. Little is known about the prevalence and relationship of youth and caregiver violence exposure to clinical outcomes among youth with perinatal human immunodeficiency virus (HIV) infection (PHIV). We evaluated associations of youth and caregiver violence exposure with unsuppressed viral load (VL) (HIV RNA > 400 copies/mL) and CD4% <25% among 8- to 15-year-old participants with PHIV in the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol. Annual clinical examination, record abstraction, and interview data were collected, including youth report of recent exposure to violence and caregivers' self-report of being assaulted/abused in adulthood. Multivariable logistic regression methods were used to calculate adjusted odds ratios for unsuppressed VL and CD4% <25%, controlling for sociodemographic characteristics. Among 268 youth with PHIV (53% girls, mean age 12.8 years, 21% white, 42% with household income <$20,000/year), 34% reported past year violence exposure; 30% had a caregiver who reported being assaulted in adulthood. One quarter of youth (24%) had unsuppressed VL and 22% had CD4% <25%. Youth who were exposed to violence in the past year versus those who were not had elevated odds of unsuppressed VL. Youth with indirect exposure to violence in the past year versus those without had elevated odds of unsuppressed VL and CD4% <25% in adjusted models. Youth with PHIV report a high prevalence of recent violence exposure, which was associated with poor virologic and immunologic outcomes. Reducing violence and providing support to youth with violence exposure and PHIV may improve health outcomes.

Metrics

7 Record Views
20 citations in Web of Science
23 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Pediatrics
Psychology, Developmental
Public, Environmental & Occupational Health
Logo image