Journal article
Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents
AIDS research and human retroviruses, v 20(5), pp 497-505
01 May 2004
PMID: 15186524
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The novel antitumor-promoting phorbol ester, prostratin, was evaluated for its ability to induce the expression of latent, highly active antiretroviral therapy (HAART)-persistent human immunodeficiency virus type I (HIV-1) from specific subsets of patients' peripheral blood cells. This evaluation was performed relative to the use of other cellular activating agents, such as OKT3, a monoclonal antibody against the human T cell receptor, interleukin-2 (IL-2), phytohemagglutinin (PHA), p24 antigen (HIV-1-specific capsid protein), and a molecular relative of prostratin, 12-deoxyphorbol 13-phenylacetate (DPP). Prostratin performed as efficiently as the other cellular activators at inducing the expression of latent HIV-1 from cells of patients on virally suppressive HAART. Of interest was the induction of a novel species of latent virus from the cells of an individual after exposure to the HIV-1-specific capsid protein, p24, relative to virus expression induced by several other cell activators. This suggests that a variety of agents may be available for animal model studies of lentiviral latency and clinical use to broadly induce the expression of latent, HAART-persistent HIV-1 in vivo with the goal of potential HIV-1 reservoir depletion or eradication.
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Details
- Title
- Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents
- Creators
- Joseph Kulkosky - Chestnut Hill CollegeJulie Sullivan - Thomas Jefferson UniversityYan XuEmily Souder - Thomas Jefferson UniversityDean H Hamer - National Cancer InstituteRoger J Pomerantz - Thomas Jefferson University
- Publication Details
- AIDS research and human retroviruses, v 20(5), pp 497-505
- Publisher
- Mary Ann Liebert
- Grant note
- AI3289 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000221763500006
- Scopus ID
- 2-s2.0-2642546509
- Other Identifier
- 991021838145204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Virology