Journal article
Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon
Biomarkers, v 1(1), pp 29-33
1996
PMID: 23888891
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
Over-expression of p21 ras-related protein was determined in the plasma by immunoblotting and in the tissue by immuno-histochemistry in a cohort of patients undergoing colonoscopy. In the plasma samples, p21 ras over-expression was detected in: 9% (4/47) of normal controls; 21% (13/61) of individuals with normal colonoscopies but with a prior history of colonic neoplasia; 12% (4/33) of small adenoma patients, 29% (6/21) of large adenoma patients; 63% (5/8) of carcinoma-in-adenoma patients; 50% (2/4) of Dukes' A carcinoma patients; and 20% (2/10) of Dukes' B-D carcinoma patients. In the tissue samples, p21 ras over-expression was detected in: 25% (2/8) of small adenoma patients; 44% (4/9) of large adenoma patients; 100% (4/4) of carcinoma-in-adenoma patients; and 33% (1/3) of Dukes' B-C carcinoma patients. For matched plasma-tissue pairs, there was a statistically significant correlation for p21 ras over-expression (R = 0.47, p = 0.02).
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Details
- Title
- Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon
- Creators
- Jiin-Chyuan Luo - Columbia UniversityAlfred I. Neugut - UPMC Hillman Cancer CenterGail Garbowski - UPMC Hillman Cancer CenterKenneth A. Forde - UPMC Hillman Cancer CenterMichael Treat - UPMC Hillman Cancer CenterSteven Smith - UPMC Hillman Cancer CenterHenry Niman - UPMC Hillman Cancer CenterPaul W. Brandt-Rauf - UPMC Hillman Cancer Center
- Publication Details
- Biomarkers, v 1(1), pp 29-33
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1996VV68300004
- Scopus ID
- 2-s2.0-0003130118
- Other Identifier
- 991019323667604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Toxicology