Journal article
Expression of p53, PCNA, and C-erbB-2 in Barrett's metaplasia and adenocarcinoma
Digestive diseases and sciences, v 42(12), pp 2453-2462
01 Dec 1997
PMID: 9440619
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We sought to determine if an immunohistochemical panel of p53, PCNA, and c-erbB-2 was a useful biomarker of transformation in Barrett's metaplasia. P53, PCNA, and c-erbB-2 immunohistochemistry was performed on resected Barrett's specimens selected to show discrete grades of dysplasia and then on prospectively obtained biopsies. In resection specimens, p53 was positive in 36% with no dysplasia, in 30% with low-grade dysplasia, in 85% with high-grade dysplasia, and in 90% of adenocarcinomas. While an evaluation of proliferation throughout the specimen did not differ between groups, surface proliferation was significantly higher in high-grade dysplasia than in low-grade or no dysplasia. All high-grade dysplasia specimens were positive for at least one marker, compared to 44% with no or low-grade dysplasia. C-erbB-2 was only seen in 31% with high-grade dysplasia and in 10% of adenocarcinomas. Prospectively, the panel had a sensitivity of 100%, a specificity of 81% and an overall accuracy of 83% in identifying patients who developed high-grade dysplasia or cancer. Thus, overexpression of p53 occurs early in the malignant transformation of Barrett's and increases with histologic progression, and proliferation at the surface of Barrett's epithelium increases with progressive grades of dysplasia. An immunohistochemical panel of p53 and PCNA is a useful biomarker for Barrett's metaplasia.
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Details
- Title
- Expression of p53, PCNA, and C-erbB-2 in Barrett's metaplasia and adenocarcinoma
- Creators
- Richard Kim - University of Pittsburgh Medical CenterMartha ClarkeMona MelhemMichelle YoungRoy U T Kim - [Retired Faculty]
- Publication Details
- Digestive diseases and sciences, v 42(12), pp 2453-2462
- Publisher
- Springer Nature B.V
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000071471100011
- Scopus ID
- 2-s2.0-0031409729
- Other Identifier
- 991019167772504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology