External microwave hyperthermia combined with radiation therapy for extensive superficial chest wall recurrences

M H Seegenschmiedt; L W Brady; G Rossmeissl

doi:10.1007/978-3-642-83260-4_21

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External microwave hyperthermia combined with radiation therapy for extensive superficial chest wall recurrences

Journal article

Peer reviewed

External microwave hyperthermia combined with radiation therapy for extensive superficial chest wall recurrences

M H Seegenschmiedt, L W Brady and G Rossmeissl

Recent results in cancer research, v 107, pp 147-151

1988

DOI: https://doi.org/10.1007/978-3-642-83260-4_21

PMID: 3375547

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Abstract

Breast Neoplasms - pathology

Combined Modality Therapy

Evaluation Studies as Topic

Humans

Hyperthermia, Induced

Microwaves

Neoplasm Recurrence, Local - radiotherapy

Neoplasm Recurrence, Local - therapy

Thoracic Neoplasms - radiotherapy

Thoracic Neoplasms - therapy

From January 1986 to January 1987 at Hahnemann University Hospital, Philadelphia, 13 patients were treated with combined external hyperthermia and radiation therapy to extensive chest wall recurrences from carcinoma of the breast. A total of 145 hyperthermia sessions for 27 different hyperthermia fields were analyzed in this study. Mixed photon (10 MV) or electron beam (6-15 MeV) radiation therapy (16-50.5 Gy, two to five weekly fractions of 1.5-2.0 Gy) was given followed within 30 min by external 915-MHz microwave hyperthermia (two weekly fractions for 60 min at 41-44 degrees C). Temperature recordings were made at up to 24 points in the center and periphery and at junctions of fields. The thermal dose concept of Sapareto (T43 Eq) was used to evaluate the relationship between maximum or minimum temperature (TMAX/TMIN) and rates of complication and of CR for each treatment field. Our results indicate that total or mean TMAX43 Eq per hyperthermia treatment field is related to complication rate, whereas total or mean TMIN43 Eq is related to CR rate. Also, higher radiation dose and smaller involved tumor area are related to higher CR rates. At 1 month follow-up 13/27 (48%) fields showed CR. At 3 months, four more CRs were noted, yielding 17/23 (74%) CR.

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Title: External microwave hyperthermia combined with radiation therapy for extensive superficial chest wall recurrences
Creators: M H Seegenschmiedt - Hahnemann University Hospital
L W Brady - Hahnemann University Hospital
G Rossmeissl - Hahnemann University Hospital
Publication Details: Recent results in cancer research, v 107, pp 147-151
Publisher: Springer Nature
Resource Type: Journal article
Language: English
Scopus ID: 2-s2.0-0023750984
Other Identifier: 3642832601; 9783642832604; 991021901309404721

External microwave hyperthermia combined with radiation therapy for extensive superficial chest wall recurrences

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