Extracellular Adenosine 5'-Triphosphate in Obstructive Airway Diseases

Amir Pelleg; Edward S. Schulman; Peter J. Barnes

doi:10.1016/j.chest.2016.06.045

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Extracellular Adenosine 5'-Triphosphate in Obstructive Airway Diseases

Journal article

Open access

Peer reviewed

Extracellular Adenosine 5'-Triphosphate in Obstructive Airway Diseases

Amir Pelleg, Edward S. Schulman and Peter J. Barnes

Chest, v 150(4), pp 908-915

Oct 2016

DOI: https://doi.org/10.1016/j.chest.2016.06.045

PMID: 27568579

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

ATP

COPD

cough

inflammation

P2 receptors

In recent years, numerous studies have generated data supporting the hypothesis that extracellular adenosine 5′-triphosphate (ATP) plays a major role in obstructive airway diseases. Studies in animal models and human subjects have shown that increased amounts of extracellular ATP are found in the lungs of patients with COPD and asthma and that ATP has effects on multiple cell types in the lungs, resulting in increased inflammation, induction of bronchoconstriction, and cough. These effects of ATP are mediated by cell surface P2 purinergic receptors and involve other endogenous inflammatory agents. Recent clinical trials reported promising treatment with P2X3R antagonists for the alleviation of chronic cough. The purpose of this review was to describe these studies and outline some of the remaining questions, as well as the potential clinical implications, associated with the pharmacologic manipulation of ATP signaling in the lungs.

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37 citations in Scopus

Details

Title: Extracellular Adenosine 5'-Triphosphate in Obstructive Airway Diseases
Creators: Amir Pelleg - Drexel University
Edward S. Schulman - Drexel University
Peter J. Barnes - Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
Publication Details: Chest, v 150(4), pp 908-915
Publisher: Elsevier
Resource Type: Journal article
Language: English
Academic Unit: Pulmonary, Critical Care, and Sleep (Medicine)
Web of Science ID: WOS:000384772800023
Scopus ID: 2-s2.0-84994545562
Other Identifier: 991019169553604721

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Collaboration types: Domestic collaboration; International collaboration
Web of Science research areas: Critical Care Medicine; Respiratory System