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Journal article
Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND
Frontiers in aging neuroscience, v 12, pp 168-168
09 Jun 2020
PMID: 32581774
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus type 1 (HIV-1)- associated neurocognitive disorders (HAND) is a disease of neurologic impairment that involves mechanisms of damage similar to other degenerative neurologic diseases such as Alzheimer's disease (AD). In the current era of antiretroviral therapy (ART), HIV-1 replication is well-suppressed, and yet, HIV-1-infected patients still have high levels of chronic inflammation, indicating that factors other than viral replication are contributing to the development of neurocognitive impairment in these patients. The underlying mechanisms of HAND are still unknown, but the HIV-1 protein, Tat, has been highlighted as a potential viral product that contributes to the development of cognitive impairment. In AD, the presence of senescent cells in the CNS has been discussed as a contributing factor to the progression of cognitive decline and may be a mechanism also involved in the development of HAND. This mini-review discusses the viral protein HIV-1 Tat, and its potential to induce senescence in the CNS, contributing to the development of HAND.
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Details
- Title
- Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND
- Creators
- Jamie Marino - Drexel UniversityBrian Wigdahl - Drexel UniversityMichael R. Nonnemacher - Drexel University
- Publication Details
- Frontiers in aging neuroscience, v 12, pp 168-168
- Publisher
- Frontiers Media Sa
- Number of pages
- 8
- Grant note
- T32 MH079785 / Ruth L. Kirschstein National Research Service Award; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Public Health Service; United States Department of Health & Human Services; United States Public Health Service P30 MH092177 / NIMH Comprehensive NeuroAIDS Center (CNAC) R01 NS089435 / National Institutes of Health from the National Institute of Neurological Disorders and Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000543864700001
- Scopus ID
- 2-s2.0-85087020338
- Other Identifier
- 991019168844404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Neurosciences