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Extracellular spike microrecordings from the subthalamic area in Parkinson’s disease
Journal article   Peer reviewed

Extracellular spike microrecordings from the subthalamic area in Parkinson’s disease

Simona Mrakic-Sposta, Sara Marceglia, Marcello Egidi, Giorgio Carrabba, Paolo Rampini, Marco Locatelli, Guglielmo Foffani, Ettore Accolla, Filippo Cogiamanian, Filippo Tamma, …
Journal of clinical neuroscience, v 15(5), pp 559-567
2008
DOI: https://doi.org/10.1016/j.jocn.2007.02.091
PMID: 18378458
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Intraoperative monitoring Microrecordings Parkinson’s disease Stereotactic neurosurgery Subthalamic nucleus
Intraoperative neuronal microrecordings can help in localizing the subthalamic nucleus (STN) during stereotactic neurosurgery for deep-brain stimulation (DBS) in Parkinson’s disease. To obtain quantitative information on neuronal spike descriptors, we systematically analysed neuronal spikes in the STN and substantia nigra pars reticulata (SNr) in 31 sides of the brain in awake patients undergoing stereotactic neurosurgery for DBS electrode implantation. In these two structures we evaluated spike amplitude, area, duration, rise time and mean total firing rate. The recording spike density was higher in the STN than in the SNr (94% vs. 28%). Microelectrode recordings showed a larger spike area and amplitude in the SNr than in the STN ([mean ± SD] amplitude: 46.7 ± 31.1 vs. 36.3 ± 29.6 μV; area: 25.6 ± 24.2 vs. 36.7 ± 21.4 μVmsec), a higher total firing rate at rest in the SNr than in the STN (78.6 ± 53.5 vs. 61.9 ± 40.8 Hz), and a longer duration and rise time in the SNr than in the STN (duration: 2.0 ± 1 vs. 1.3 ± 0.6 ms; rise time: 0.95 ± 0.6 vs. 0.67 ± 0.3 ms). Our analysis also revealed sex-related differences in the studied spike descriptors, paralleling recent findings from deep electroencephalography recordings. In the STN, males had larger spike area and amplitude (amplitude: 41.97 ± 32.57 vs. 26.2 ± 19.7 μV; area: 31.8 ± 26.4 vs. 13.0 ± 10.6 μVmsec), whereas females had higher mean total firing rate (66.7 ± 53.4 vs. 82.8 ± 50.8 Hz). Our results have implications for clinical practice and the development of algorithms for the neurophysiological identification of the STN during stereotactic neurosurgery for Parkinson’s disease, based on the on-line automated computation of multiple spike-variables.

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16 citations in Web of Science
16 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Clinical Neurology
Neurosciences
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