Extracorporeal immunoadsorption of plasma from a metastatic colon carcinoma patient by protein a‐containing nonviable staphylococcus aureus. Clinical, biochemical, serologic, and histologic evaluation of the Patient's response

P. K. Ray; A. Idiculla; R. Mark; J. E. Rhoads; H. Thomas; J. G. Bassett; D. R. Cooper

doi:10.1002/1097-0142(19820501)49:9<1800::AID-CNCR2820490912>3.0.CO;2-6

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Extracorporeal immunoadsorption of plasma from a metastatic colon carcinoma patient by protein a‐containing nonviable staphylococcus aureus. Clinical, biochemical, serologic, and histologic evaluation of the Patient's response

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Extracorporeal immunoadsorption of plasma from a metastatic colon carcinoma patient by protein a‐containing nonviable staphylococcus aureus. Clinical, biochemical, serologic, and histologic evaluation of the Patient's response

P. K. Ray, A. Idiculla, R. Mark, J. E. Rhoads, H. Thomas, J. G. Bassett and D. R. Cooper

Cancer, v 49(9), pp 1800-1809

01 May 1982

DOI: https://doi.org/10.1002/1097-0142(19820501)49:9<1800::AID-CNCR2820490912>3.0.CO;2-6

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Abstract

A patient with a metastatic colon carcinoma was treated by immunoadsorption (IA) therapy using heat‐killed, formalin‐stabilized protein A‐containing Staphylococcus aureus Cowan I as the immunoadsorbent. The patient experienced both subjective and objective positive clinical response without undue morbidity. The patient's response correlated well with laboratory findings of decreased concentrations of carcinoembryonic antigen (CEA), immunoglobulin G (IgG), immune complexes (IC) and histopathologic data. The patient underwent surgery following 15 IA treatments; she lived for eighteen months post‐treatment.

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Title: Extracorporeal immunoadsorption of plasma from a metastatic colon carcinoma patient by protein a‐containing nonviable staphylococcus aureus. Clinical, biochemical, serologic, and histologic evaluation of the Patient's response
Creators: P. K. Ray - Pennsylvania Hospital
A. Idiculla - Department of Surgery, Alma Dea Morani Laboratory of Surgical Immunobiology, Philadelphia, Pennsylvania
R. Mark - Pennsylvania Hospital
J. E. Rhoads - Department of Surgery, Alma Dea Morani Laboratory of Surgical Immunobiology, Philadelphia, Pennsylvania
H. Thomas - Alma
J. G. Bassett - Department of Surgery, Alma Dea Morani Laboratory of Surgical Immunobiology, Philadelphia, Pennsylvania
D. R. Cooper - Department of Surgery, Alma Dea Morani Laboratory of Surgical Immunobiology, Philadelphia, Pennsylvania
Publication Details: Cancer, v 49(9), pp 1800-1809
Publisher: Wiley Subscription Services, Inc., A Wiley Company
Number of pages: 10
Grant note: Fannie E. Rippel Foundation R. J. Reynolds Industries, Inc.
Resource Type: Journal article
Language: English
Academic Unit: Surgery
Web of Science ID: WOS:A1982NL22000011
Scopus ID: 2-s2.0-0020080050
Other Identifier: 991019184193004721

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Web of Science research areas: Oncology

Extracorporeal immunoadsorption of plasma from a metastatic colon carcinoma patient by protein a‐containing nonviable staphylococcus aureus. Clinical, biochemical, serologic, and histologic evaluation of the Patient's response

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