Journal article
Eye movements organize excitability state, information coding and network connectivity in the human hippocampus
Progress in neurobiology, v 252, 102812
01 Sep 2025
PMID: 40816703
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Natural vision is an active sensing process that entails frequent eye movements to sample the environment. Nonetheless vision is often studied using passive viewing with eye position held constant. Using closed-loop eye-tracking, with saccade-contingent stimulation and simultaneous intracranial recordings in surgical epilepsy patients, we tested the critical role of eye movement signals during natural visual processing in the hippocampus and hippocampal-amygdala circuit. Prior work shows that saccades elicit phase reset of ongoing neural excitability fluctuations across a broad array of cortical and subcortical areas. Here we show that saccade-related phase reset systematically modulates neuronal ensemble responses to visual input, enables phase-coding of information across the saccade-fixation cycle and modulates network connectivity between hippocampus and amygdala. The saccade-fixation cycle thus emerges as a fundamental sampling unit, organizing a range of neural operations including input representation, network connectivity and information coding. Saccade-fixation cycle: a fundamental sampling unit, organizing input representation, information coding and network coordination.
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Details
- Title
- Eye movements organize excitability state, information coding and network connectivity in the human hippocampus
- Creators
- Marcin Leszczynski - Jagiellonian UniversityElizabeth Espinal - Feinstein Institute for Medical ResearchElliot Smith - University of UtahCatherine Schevon - Columbia UniversitySameer Sheth - Baylor College of MedicineCharles E. Schroeder - Nathan Kline Institute for Psychiatric Research
- Publication Details
- Progress in neurobiology, v 252, 102812
- Publisher
- Elsevier
- Grant note
- Narodowe Centrum Nauki (http://data.elsevier.com/vocabulary/SciValFunders/501100004281) 2022/45/B/HS6/04097 / Narodowe Centrum Nauki (http://data.elsevier.com/vocabulary/SciValFunders/501100004281)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001565859500001
- Scopus ID
- 2-s2.0-105013992784
- Other Identifier
- 991022197428404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences