Journal article
FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques
Journal of neuroimmune pharmacology, v 13(2), pp 204-218
Jun 2018
PMID: 29288344
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cerebrospinal fluid (CSF) drains via the lymphatic drainage pathway. This lymphatic pathway connects the central nervous system (CNS) to the cervical lymph node (CLN). As the CSF drains to CLN via the dural and nasal lymphatics, T cells and antigen presenting cells pass along the channels from the subarachnoid space through the cribriform plate. Human immunodeficiency virus (HIV) may also egress from the CNS along this pathway. As a result, HIV egressing from the CNS may accumulate within the CLN. Towards this objective, we analyzed CLNs isolated from rhesus macaques that were chronically-infected with simian immunodeficiency virus (SIV). We detected significant accumulation of SIV within the CLNs. SIV virion trapping was observed on follicular dendritic cells (FDCs) localized within the follicular regions of CLNs. In addition, SIV antigens formed immune complexes when FDCs interacted with B cells within the germinal centers. Subsequent interaction of these B cells with CD4+ T follicular helper cells (T) resulted in infection of the latter. Of note, 73% to 90% of the T cells within CLNs were positive for SIV p27 antigen. As such, it appears that not only do the FDCs retain SIV they also transmit them (via B cells) to T within these CLNs. This interaction results in infection of T
in the CLNs. Based on these observations, we infer that FDCs within the CLNs have a novel role in SIV entrapment with implications for viral trafficking.
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Details
- Title
- FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques
- Creators
- Rajnish S Dave - University of Nebraska Medical CenterRavi K Sharma - Post Graduate Institute of Medical Education and ResearchRoshell R Muir - Drexel University, Infectious Diseases (and HIV Medicine)Elias Haddad - Drexel University, Infectious Diseases (and HIV Medicine)Sanjeev Gumber - Emory UniversityFrancois Villinger - University of Louisiana at LafayetteArtinder P Nehra - Drexel University, Microbiology and ImmunologyZafar K Khan - Drexel University, Microbiology and ImmunologyBrian Wigdahl - Drexel University, Microbiology and ImmunologyAftab A Ansari - Emory UniversitySiddappa N Byrareddy - University of Nebraska Medical CenterPooja Jain - Drexel University, Microbiology and Immunology
- Publication Details
- Journal of neuroimmune pharmacology, v 13(2), pp 204-218
- Publisher
- Springer Nature; United States
- Number of pages
- 15
- Grant note
- R01 AI113883 / NIAID NIH HHS R21 MH113455 / NIMH NIH HHS R01 NS097147 / NINDS NIH HHS P51 OD011132 / NIH HHS R21 AI114415 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000431210500007
- Scopus ID
- 2-s2.0-85039696833
- Other Identifier
- 991014877674204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy