Journal article
Fabrication, Characterization, and Biocompatibility of Single-Walled Carbon Nanotube-Reinforced Alginate Composite Scaffolds Manufactured Using Freeform Fabrication Technique
Journal of biomedical materials research. Part B, Applied biomaterials, v 87B(2), pp 406-414
01 Nov 2008
PMID: 18506813
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Composite polymeric scaffolds from alginate and single-walled carbon nanotube (SWCNT) were produced using a freeform fabrication technique. The scaffolds were characterized for their structural, mechanical, and biological properties by scanning electron microscopy, Raman spectroscopy, tensile testing, and cell-scaffold interaction study. Three-dimensional hybrid alginate/SWCNT tissue scaffolds were fabricated in a multinozzle biopolymer deposition system, which makes possible to disperse and align SWCNTs in the alginate matrix. The structure of the resultant scaffolds was significantly altered due to SWCNT reinforcement, which was confirmed by Raman spectroscopy. Microtensile testing presented a reinforcement effect of SWCNT to the mechanical strength of the alginate struts. Ogden constitutive modeling was utilized to predict the stress-strain relationship of the alginate scaffold, which compared well with the experimental data. Cellular study by rat heart endothelial cell showed that the SWCNT incorporated in the alginate structure improved cell adhesion and proliferation. Our study suggests that hybrid alginate/SWCNT scaffolds are a promising biomaterial for tissue engineering applications. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 87B: 406-414, 2008
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Details
- Title
- Fabrication, Characterization, and Biocompatibility of Single-Walled Carbon Nanotube-Reinforced Alginate Composite Scaffolds Manufactured Using Freeform Fabrication Technique
- Creators
- Eda D. Yildirim - Drexel UniversityXi Yin - Drexel UniversityKalyani Nair - Drexel UniversityWei Sun - Drexel University
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, v 87B(2), pp 406-414
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- 0427216; 0219176 / NSF; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000260355000013
- Scopus ID
- 2-s2.0-55049135014
- Other Identifier
- 991019167646404721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials