Journal article
Fabrication, biodegradation behavior and cytotoxicity of Mg-nanodiamond composites for implant application
Journal of materials science. Materials in medicine, v 26(2), pp 1-9
01 Feb 2015
PMID: 25665844
Abstract
Mg-based biodegradable implants offer several advantages over their non-degradable or degradable polymeric counterparts used today. However, the low corrosion resistance of Mg in physiologic environment remained as concerns. In this research, nanodiamond (ND) was uniformly dispersed in Mg matrix to induce a protective layer on Mg surface during corrosion. Compared with pure Mg, fabricated Mg-ND nanocomposites had lower corrosion rates, higher corrosion potential, and higher corrosion resistance. Specifically, the corrosion rate of Mg was reduced by 4.5 times by adding 5 wt% of ND particles. Corrosion inhibition effect of ND was thus validated. The chemical interaction and physical adsorption of the ions from simulated body fluid on ND might be the main reason for enhanced corrosion resistance. In vitro biocompatibility test results indicated that Mg-ND nanocomposites were biocompatible since cells growing in contact with corrosion products of Mg-ND maintained high cell viability and healthy morphology. Therefore, Mg-ND nanocomposites with homogenous ND dispersion, enhanced corrosion resistance, and good biocompatibility might be an excellent candidate material for biodegradable implant application.
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Details
- Title
- Fabrication, biodegradation behavior and cytotoxicity of Mg-nanodiamond composites for implant application
- Creators
- Haibo Gong - Drexel UniversityBabak Anasori - Drexel UniversityChris R. Dennison - Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USAKun Wang - Rowan UniversityE. Caglan Kumbur - Drexel UniversityRandy Strich - Rowan UniversityJack G. Zhou - Drexel University
- Publication Details
- Journal of materials science. Materials in medicine, v 26(2), pp 1-9
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- CMMI-0927963 / NSF; National Science Foundation (NSF) R01GM113052 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000349402400049
- Scopus ID
- 2-s2.0-84922809991
- Other Identifier
- 991019173665504721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials