Journal article
Fabrication of Hard-Soft Microfluidic Devices Using Hybrid 3D Printing
Micromachines (Basel), v 11(6), p567
01 Jun 2020
PMID: 32492980
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Widely accessible, inexpensive, easy-to-use consumer 3D printers, such as desktop stereolithography (SLA) and fused-deposition modeling (FDM) systems are increasingly employed in prototyping and customizing miniaturized fluidic systems for diagnostics and research. However, these 3D printers are generally limited to printing parts made of only one material type, which limits the functionality of the microfluidic devices without additional assembly and bonding steps. Moreover, mating of different materials requires good sealing in such microfluidic devices. Here, we report methods to print hybrid structures comprising a hard, rigid component (clear polymethacrylate polymer) printed by a low-cost SLA printer, and where the first printed part is accurately mated and adhered to a second, soft, flexible component (thermoplastic polyurethane elastomer) printed by an FDM printer. The prescribed mounting and alignment of the first-printed SLA-printed hard component, and its pre-treatment and heating during the second FDM step, can produce leak-free bonds at material interfaces. To demonstrate the utility of such hybrid 3D-printing, we prototype and test three components: i) finger-actuated pump, ii) quick-connect fluid coupler, and iii) nucleic acid amplification test device with screw-type twist sealing for sample introduction.
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Details
- Title
- Fabrication of Hard-Soft Microfluidic Devices Using Hybrid 3D Printing
- Creators
- Carlos Ruiz - University of PennsylvaniaKarteek Kadimisetty - University of PennsylvaniaKun Yin - UConn HealthMichael G. Mauk - Univ Penn, Dept Mech Engn & Appl Mech, 220 South 33rd St, Philadelphia, PA 19104 USAHui Zhao - University of Nevada, Las VegasChangchun Liu - University of Pennsylvania
- Publication Details
- Micromachines (Basel), v 11(6), p567
- Publisher
- Mdpi
- Number of pages
- 11
- Grant note
- R01EB023607; R01CA214072 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 2016-08811 / USDA National Institute of Food and Agriculture, AFRI project
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Engineering Technology
- Web of Science ID
- WOS:000551632500001
- Scopus ID
- 2-s2.0-85087495478
- Other Identifier
- 991020623758804721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Analytical
- Instruments & Instrumentation
- Nanoscience & Nanotechnology
- Physics, Applied